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魏文胜
研究员

  • E-mail:wswei@pku.edu.cn
  • 办公电话:+86-010-62757227
    办公地点:北京大学生命科学学院202室
    邮件地址:北京市海淀区颐和园路5号北京大学生命科学学院202室,100871
    研究组主页:http://www.bio.pku.edu.cn/teacher_dis_oa.php?cid=208&&teaid=78
  • 理学博士,Michigan State University,1999,遗传

    理学学士,北京大学,1991,生物化学

    工作经历
  • 2016-现在,北京未来基因诊断高精尖创新中心,研究员

    2014-现在,北京大学BIOPIC,研究员

    2007-现在,北京大学生命科学学院,研究员

    2005-2007,美国斯坦福大学医学院遗传系,助理研究员

    1999-2004,美国斯坦福大学医学院遗传系,博士后

    1991-1993,北京大学生命中心,技术员

    主要研究方向
  • 致力于发展基因组编辑技术、功能基因组学以及基因治疗;在此基础上研究癌症、感染等重大疾病发生机制,为发展高效治疗手段提供新的药物靶点和思路。
    获奖及荣誉
  • 2016,中国专利优秀奖

    2016,谈家桢生命科学创新奖

    2016,《科学中国人》年度人物

    2015,北京大学郑昌学教学优秀奖

    2014,拜耳学者奖

    2014,罗氏中国青年学者奖

    2012,北京大学通化东宝生命科学奖

    2010,北京大学生命科学学院最受学生欢迎奖

    代表性论文及论著
    • 15. Fan H, Qiao L, Kang KD, Fan J, Wei W and Luo G. Attachment and Postattachment Receptors Important for Hepatitis C Virus Infection and Cell-to-Cell Transmission. Journal of virology. 2017;91.
      14. Zhang Y, Liu L, Guo S, Song J, Zhu C, Yue Z, Wei W and Yi C. Deciphering TAL effectors for 5-methylcytosine and 5-hydroxymethylcytosine recognition. Nat Commun. 2017;8:901.
      13. Zhu S, Zhou Y and Wei W. Genome-Wide CRISPR/Cas9 Screening for High-Throughput Functional Genomics in Human Cells. Methods in molecular biology (Clifton, NJ). 2017;1656:175-181.
      12. He R, Peng J, Yuan P, Yang J, Wu X, Wang Y and Wei W. Glucosyltransferase Activity of Clostridium difficile Toxin B Triggers Autophagy-mediated Cell Growth Arrest. Sci Rep. 2017;7:10532.
      11. Hu H, Zhang H, Wang S, Ding M, An H, Hou Y, Yang X, Wei W, Sun Y and Tang C. Live visualization of genomic loci with BiFC-TALE. Sci Rep. 2017;7:40192.
      10. Zhou Y, Wang P, Tian F, Gao G, Huang L, Wei W and Xie XS. Painting a specific chromosome with CRISPR/Cas9 for live-cell imaging. Cell Res. 2017;27:298-301.

    • 9. He R, Peng J, Yuan P, Xu F, Wei W*. (2015) Divergent roles of BECN1 in LC3 lipidation and autophagosomal function. Autophagy (in press).

    • 8. Yuan P, Zhang H, Cai C, Zhu S, Zhou Y, Yang X, He R, Li C, Guo S, Li S, Huang T, Feng H and Wei W*. (2014) Identification of the Cellular Receptor for Clostridium difficile Toxin B. Cell Res. doi: 10.1038/cr.2014.169.

    • 7. Zhou Y, Zhu S, Cai C, Yuan P, Li C, Huang Y and Wei W*. (2014) High-throughput Screening of a CRISPR/Cas Library for Functional Genomics in Human Cells. Nature 509(7501): 487-91.

    • 6. Qian LL, Cai CZ, Yuan PF, Jeong SY, Yang XZ, Almeida VD, Ernst J, Costa M, Cohen SN, Wei WS*. Bidirectional effect of Wnt signaling antagonist DKK1 on the modulation of anthrax toxin uptake. Sci China Life Sci, 2014, 57: 469–481.

    • 5. Yang J, Zhang Y, Yuan P, Cai C, Ren Q, Guo S, Zhu C, Qi H and Wei W*. (2014) A Complete Decoding of DNA Recognition by TAL Effector RVDs. Cell Res. 24:628-631.

    • 4. Yang J, Yuan P, Wen D , Sheng Y, Zhu S, Yu Y, Gao X and Wei W*. (2013) ULtiMATE system for rapid assembly of customized TAL effectors. PLoS One 2013; 8:e75649.

    • 3. Wei W*, Lu Q., Chaudry J, Leppla S, Cohen SN. (2006) The LDL receptor-related protein LRP6 mediates internalization and lethality of anthrax toxin. Cell 124, 1141-1154.

    • 2. Wei W*, PlovanichJones A, Deng W, Jin Q, Collmer A, Huang H, and He SY. (2000) The gene coding for the Hrp pilus structural protein is required for type III secretion of Hrp and Avr proteins in Pseudomonas syringae pv. tomato. Proc. Natl. Acad. Sci. USA 97, 2247-52.

    • 1. Roine E, Wei W*, Yuan J, Nurmiaho-Lassila EL, Kalkkinen N, Romantschuk M, He SY. (1997) Hrp pilus: an hrp-dependent bacterial surface appendage produced by Pseudomonas syringae pv. tomato DC3000. Proc. Natl. Acad. Sci. USA 94, 3459-64. (*Co-first author)