您的位置:首页 > 中心成员 > 中心教师

赵新生
研究员

  • E-mail:zhaoxs#pku.edu.cn
  • 办公电话:+86-10-6275.1727
    办公地点:北京大学综合科研楼生物动态光学成像中心332室
    邮件地址:北京市海淀区颐和园路5号北京大学综合科研楼生物动态光学成像中心,100871
    研究组主页:http://www.chem.pku.edu.cn/zhaoxs/
  • 哲学博士,美国加州大学伯克利分校,1988,化学
    理学硕士,北京大学,1984,化学
    理学学士,北京大学,1982,化学 
     

    工作经历
  • 2010-现在,北京大学生物动态光学成像中心研究员

    2000-现在,北京大学化学与分子工程学院长江特聘教授

    1992-2000,北京大学化学与分子工程学院,教授

    1990-1992,北京大学化学系,副教授

    1989-1990,美国麻省理工学院,博士后

    1984-1990,北京大学化学系,讲师

    主要研究方向
  • 主要研究兴趣是以单分子探测技术为主研究生物分子反应,特别是酶对核酸进行化学修饰和细菌对外膜蛋白进行保护和质量控制过程的微观动力学机理。
    获奖及荣誉
    代表性论文及论著
  • 15. Huimin Bi, Yandong Yin, Bailong Pan, Geng Li, Xin Sheng Zhao*, J. Phys. Chem. Lett. 2016, 7 (10) 1865-1871. “Scanning Single-Molecule Fluorescence Correlation Spectroscopy Enables Kinetics Study of DNA Hairpin Folding with a Time Window from Microseconds to Seconds”. DOI: 10.1021/acs.jpclett.6b00720

    14. Zhenqin Wu?, Huimin Bi?, Sichen Pan, Lingyi Meng, Xin Sheng Zhao*, J. Phys. Chem. B 2016, 120 (45), 11674-11682. “Determination of equilibrium constant and relative brightness in fluorescence correlation spectroscopy by considering third-order correlations”. DOI: 10.1021/acs.jpcb.6b07953

    13. Peng Wang, Lijiang Yang, Yi Qin Gao*, Xin Sheng Zhao*, Nucleic Acids Res. 2015, 43 (15) September 3, 7207-7216. “Accurate Placement of Substrate RNA by Gar1 in H/ACA RNA-guided Pseudouridylation”. doi: 10.1093/nar/gkv757

    12. Zhi Xin Lyu, Xin Sheng Zhao*, Biochem. Soc. Trans. 2015, 43 (2) April 7, 133-138. “Periplasmic Quality Control in Biogenesis of Outer Membrane Proteins”. doi:10.1042/BST20140217

    11. Yandong Yin, Lijiang Yang, Guanqun Zheng, Chan Gu, Chengqi Yi, Chuan He, Yi Qin Gao, and Xin Sheng Zhao, PNAS 2014, 111 (22), 8043 – 8048. “Dynamics of spontaneous flipping of a mismatched base in DNA duplex”.

    10. Peng Wang, Lijiang Yang, Pengcheng Liu, Yi Qin Gao, and Xin Sheng Zhao, Chem.-Eur. J. 2013, 19, 5909. “Single Molecule Detection Reveals Knot Sliding in TrmD Denaturation”.

    9. Xinxing Yang, Jingqi Duan, Shuang Li, Peng Wang, Shoucai Ma, Keqiong Ye, Xin Sheng Zhao, Nucleic Acids Res. 2012, 40, 10925. “Kinetic and thermodynamic characterization of the reaction pathway of box H/ACA RNA-guided pseudouridine formation”.

    8. Si Wu, Xi Ge, Zhixin Lv, Zeyong Zhi, Zengyi Chang, and Xin Sheng Zhao, Biochem. J. 2011, 438, 505. "Interaction between Bacterial Outer Membrane Proteins and Periplasmic Quality Control Factors: A Kinetic Partitioning Mechanism".

    7. Yandong Yin, Xin Sheng Zhao, Acc. Chem. Res. 2011, 44, 1172. "Kinetics and dynamics of DNA hybridization".

    6. 赵新生,《中级物理化学》,北京大学出版社,北京 2010

    5. Xudong Chen, Yan Zhou, Peng Qu, Xin Sheng Zhao, J. Am. Chem. Soc. 2008, 130, 16947. "Base-by-Base Dynamics in DNA Hybridization Probed by Fluorescence Correlation Spectroscopy".

    4. Chunlai Chen, Wenjuan Wang, Zhang Wang, Fang Wei and Xin Sheng Zhao, Nucleic Acids Res. 2007, 35, 2875. "Influence of secondary structure on kinetics and reaction mechanism of DNA hybridization".

    3. Yinghua Guan, Zheng Wang, Aoneng Cao, Luhua Lai, and Xin Sheng Zhao, J. Am. Chem. Soc. 2006, 128, 7203. "Subunit Exchange of MjHsp16.5 Studied by Single-Molecule Imaging and Fluorescence Resonance Energy Transfer".

    2. Fang Wei, Chunlai Chen, Lin Zhai, Ning Zhang, and Xin Sheng Zhao, J. Am. Chem. Soc. 2005, 127, 5306. "Recognition of Single Nucleotide Polymorphisms using Scanning Potential Hairpin Denaturation".

    1. 赵新生,《化学反应理论导论》,北京大学出版社,北京 2003