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汤富酬
研究员

  • E-mail:tangfuchou#pku.edu.cn
  • 办公电话:+86-10-6274.4062
    办公地点:北京大学综合科研楼生物动态光学成像中心309室
    邮件地址:北京市海淀区颐和园路5号北京大学综合科研楼生物动态光学成像中心,100871
    研究组主页:
  • 理学博士,北京大学,2003,生物学
    理学学士,北京大学,1998,生物学

    工作经历
  • 2016.8-现在,北京未来基因诊断高精尖创新中心,研究员

    2015-现在,北大-清华生命科学联合中心,研究员

    2010-现在,北京大学BIOPIC,研究员

    2004-2010,英国剑桥大学Gurdon研究所,博士后

    主要研究方向
  • 具有自我更新能力和分化潜能的干细胞是哺乳动物胚胎发育过程中以及成体中的关键种类的细胞,对各种干细胞进行深入研究是理解哺乳动物发育、生长机制的关键,也是将干细胞应用于临床再生医学、治疗人类疾病的前提。本实验室主要围绕哺乳动物早期胚胎发育研究多能性干细胞分化、发育调控的分子机理,特别是表观遗传学调控机理,以及相关的原始生殖细胞(Primordial Germ cells)发育过程中的表观遗传学重编程机理。利用我们发展的单细胞转录组测序技术(single cell RNA-Seq transcriptome analysis)、单细胞DNA甲基化组分析技术(Single cell RRBS),以及单细胞基因组测序技术(Single cell genome sequencing)、染色体免疫共沉淀-测序技术(ChIP-Seq)、早期胚胎显微操作技术深入分析哺乳动物早期胚胎以及多能性干细胞中基因表达网络的表观遗传学调控机理。
    获奖及荣誉
  • 2016,第九届谈家桢生命科学创新奖

    2016,第二届普洛麦格生物化学奖

    2016,国家自然科学基金委,杰出青年基金

    2016,“揭示人类原始生殖细胞基因表达与表观遗传调控特征”项目成果入选“2015年度中国科学十大进展”

    2015,“顾孝诚讲座奖”

    2015,“精确推演母源基因组信息”入选"2014年度中国科学十大进展"

    2013,国家自然科学基金委,优秀青年基金


    代表性论文及论著
  • 19.  Zhou F, Li X, Wang W, Zhu P, Zhou J, He W, Ding M, Xiong F, Zheng X, Li Z, Ni Y, Mu X, Wen L, Cheng T, Lan Y, Yuan W*, Fuchou Tang*, Liu B*. Tracing haematopoietic stem cell formation at single-cell resolution. Nature, 533: 487-492 (2016) (*: Co-corresponding authors).

    18.  Guo H, Hu B, Yan L, Yong J, Wu Y, Gao Y, Guo F, Hou Y, Fan X, Dong J, Wang X, Zhu X, Yan J, Wei Y, Jin H, Zhang W, Wen L, Fuchou Tang*, Qiao J*. DNA methylation and chromatin accessibility profiling of mouse and human fetal germ cells. Cell Research, doi: 10.1038/cr.2016.128 (2016) (*: Co-corresponding authors).

    17.  Wen L*, Tang Fuchou*. Single-cell sequencing in stem cell biology. Genome Biology 17: 71 (2016) (*: Co-corresponding authors) (Review).

    16.  Dang Y, Yan L, Hu B, Fan X, Ren Y, Li R, Lian Y, Yan J, Li Q, Zhang Y, Li M, Ren X, Huang J, Wu Y, Liu P, Wen L, Zhang C, Huang Y*, Tang Fuchou*, Qiao J*. Tracing the expression of circular RNAs in human pre-implantation embryos. Genome Biology 17: 130 (2016) (*: Co-corresponding authors).

    15.  Hou Y, Guo H, Cao C, Li X, Hu B, Zhu P, Wu X, Wen L, Tang Fuchou*, Huang Y*, Peng J*. Single-cell triple omics sequencing reveals genetic, epigenetic, and transcriptomic heterogeneity in hepatocellular carcinomas. Cell Research 26: 304-319 (2016) (*: Co-corresponding authors).

    14.  Pan H, Guan D, Liu X, Li J, Wang L, Wu J, Zhou J, Zhang W, Ren R, Zhang W, Li Y, Yang J, Hao Y, Yuan T, Yuan G, Wang H, Ju Z, Mao Z, Li J, Qu J*, Tang Fuchou*, Liu GH*. SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2. Cell Research 26: 190-205 (2016) (*: Co-corresponding authors).

    13. Zhou F, Li X, Wang W, Zhu P, Zhou J, He W, Ding M, Xiong F, Zheng X, Li Z, Ni Y, Mu X, Wen L, Cheng T, Lan Y, Yuan W*, Fuchou Tang*, Liu B*. Tracing haematopoietic stem cell formation at single-cell resolution. Nature, 533: 487-492 (2016) (*: 共同通讯作者).

    12. Fan X, Zhang X, Wu X, Guo H, Hu Y, Tang Fuchou*, Huang Y*. Single-cell RNA-seq transcriptome analysis of linear and circular RNAs in mouse preimplantation embryos. Genome Biology 16: 148 (2015) (*: 共同通讯作者).

    11. Guo H, Zhu P, Guo F, Li X, Wu X, Fan X, Wen L*, Tang Fuchou*. Profiling DNA methylome landscapes of mammalian cells with single-cell reduced-representation bisulfite sequencing. Nature Protocols 10: 645-659 (2015) (*: 共同通讯作者).

    10. Wen L*, Tang Fuchou*, How to catch rare cell types. Nature 2015; doi:10.1038/nature15204 (*: Co-corresponding authors) (Preview). 

    9. Guo F, Yan L, Guo H, Li L, Hu B, Zhao Y, Yong J, Hu Y, Wang X, Wei Y, Wang W, Li R, Yan J, Zhi X, Zhang Y, Jin H, Zhang W, Hou Y, Zhu P, Li J, Zhang L, Liu S, Ren Y, Zhu X, Wen L, Gao YQ, Tang Fuchou*, Qiao J*. The transcriptome and DNA methylome landscapes of human primordial germ cells. Cell 2015; 161: 1437-1452 (*: Co-corresponding authors). 

    8. Zhang W, Li J, Suzuki K, Qu J, Wang P, Zhou J, Liu X, Ren R, Xu X, Ocampo A, Yuan T, Yang J, Li Y, Shi L, Guan D, Pan H, Duan S, Ding Z, Li M, Yi F, Bai R, Wang Y, Chen C, Yang F, Li X, Wang Z, Aizawa E, Goebl A, Soligalla RD, Reddy P, Esteban CR, Tang Fuchou*, Liu GH*, Belmonte JC*. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging. Science 2015; 348: 1160-1163 (*: Co-corresponding authors). 

    7. Wen L*, Tang Fuchou*, Charting a Map through the Cellular Reprogramming Landscape. Cell Stem Cell 2015; 16: 215-216 (*: Co-corresponding authors) (Preview). 

    6. Guo H, Zhu P, Yan L, Li R, Hu B, Lian Y, Yan J, Ren X, Lin S, Li J, Jin X, Shi X, Liu P, Wang X, Wang W, Wei Y, Li X, Guo F, Wu X, Fan X, Yong J, Wen L, Xie SX, Tang Fuchou*, Qiao J*. The DNA methylation landscape of human early embryos. Nature 2014; 511: 606-610 (*: Co-corresponding authors). 

    5. Guo F, Li X, Liang D, Li T, Zhu P, Guo H, Wu X, Wen L, Gu TP, Hu B, Walsh CP, Li J*, Tang Fuchou*, Xu GL*. Active and Passive Demethylation of Male and Female Pronuclear DNA in the Mammalian Zygote. Cell Stem Cell 2014; 15: 447-458 (*: Co-corresponding authors). 

    4. Wen L, Tang Fuchou*, Reconstructing Complex Tissues from Single-Cell Analyses. Cell 2014; 157: 771-773 (*: Corresponding author). 

    3. Hou Y, Fan W, Yan L, Li R, Lian Y, Huang J, Li J, Xu L, Tang Fuchou*, Xie XS*, Qiao J*. Genome Analyses of Single Human Oocytes. Cell 2013; 155: 1492-1506 (*: Co-corresponding authors). 

    2. Guo H, Zhu P, Wu X, Li X, Wen L, Tang Fuchou*. Single-cell methylome landscapes of mouse embryonic stem cells and early embryos analyzed using reduced representation bisulfite sequencing. Genome Research 2013; 23: 2126-2135 (*: Corresponding author). 

    1. Yan L, Yang M, Guo H, Yang L, Wu J, Li R, Liu P, Lian Y, Zheng X, Yan J, Huang J, Li M, Wu X, Wen L, Lao K, Li R*, Qiao J*, Tang Fuchou*. Single-cell RNA-Seq profiling of human preimplantation embryos and embryonic stem cells. Nature Structural & Molecular Biology 2013; 20: 1131-1139 (*: Co-corresponding authors).