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副研究员

  • E-mail:wenlu#pku.edu.cn
  • 办公电话:+86-10-6275.5246(4050)
    办公地点:北京大学综合科研楼生物动态光学成像中心308室
    邮件地址:北京市海淀区颐和园路5号北京大学生物动态光学成像中心,100871
    研究组主页:
  • 理学博士,中南大学医学遗传学国家重点实验室,2004,遗传学
    医学硕士,中南大学湘雅医学院,2000,神经外科学
    医学学士,中南大学湘雅医学院,2000,临床医学(七年制本硕连读)

    工作经历
  • 2005-2008,北京大学生命科学学院,博士后

    2009-2010,中山大学生命科学学院,讲师

    2011-2016,北京大学生物动态光学成像中心,助理研究员

    2017-现在,北京大学生物动态光学成像中心,副研究员


    主要研究方向
  • 单细胞基因组与表观基因组学
    获奖及荣誉
    代表性论文及论著
  • 1.     Wen L* and Tang F*. Single-cell sequencing in stem cell biology. Genome Biology, 2016, 17:71. (Review, *: co-corresponding authors)

    2.     Wen L#, Li J#, Guo H#, Liu X#, Zheng S, Wen L, Li J, Guo H, Liu X, Zheng S, Zhang D, Zhu W, Qu J, Guo L, Du D, Jin X, Zhang Y, Gao Y, Shen J, Ge H, Tang F, Huang Y, Peng J. Genome-scale detection of hypermethylated CpG islands in circulating cell-free DNA of hepatocellular carcinoma patients. Cell Research, 2015 (25): 1250-1264. (#:co-first authors)

    3.     Guo H, Zhu P, Guo F, Li XL, Wu X, Fan X, Wen L*, Tang F*. Profiling DNA methylome landscapes of mammalian cells with single-cell reduced-representation bisulfite sequencing. Nature Protocol, 2015(5): 645-59. (*:co-corresponding authors) 

    4.     Wen L*, Tang F*. How to catch rare cell types. Nature, 2015, 525(7568):197-8. (Preview, Nature 2015 Editors' choice, *: co-corresponding authors)

    5.     Wen L*, Tang F*. Charting a map through the cellular reprogramming landscape. Cell Stem Cell. 2015 Mar 5;16(3):215-6. (Preview, *: co-corresponding authors)

    6.     Wen L#, Li X#, Yan L#, Tan Y#, Li R, Zhao Y, Wang Y, Xie J, Zhang Y, Song C, Yu M, Liu X, Zhu P, Li X, Hou Y, Guo H, Wu X, He C, Li R, Tang F, Qiao J. Whole-genome analysis of 5-hydroxymethylcytosine and 5-methylcytosine at base resolution in the human brain. Genome Biology. 2014, 15(3):R49. (#:co-first authors)

    7.     Wen L and Tang F. Reconstructing complex tissues from single-cell analyses. Cell, 2014(157): 771-773. (Preview)

    8.     Wen L* and Tang F. Genomic distribution and possible functions of DNA hydroxymethylation in the brain. Genomics. 2014, 104(5): 341–346. (Review, *: corresponding author)

    9.     Gan H#, Wen L#, Liao S#, Lin X, Ma T, Liu J, Song CX, Wang M, He C, Han C, Tang F. Dynamics of 5-hydroxymethylcytosine during mouse spermatogenesis. Nature Communication. 2013 Jun 13; 4:1995. (#:co-first authors)

    10.   Lan X#, Wen L#*, Li K, Liu X, Luo B, Chen F, Xie D, Kung H. Comparative analysis of duplicated sox21 genes in zebrafish. Development Growth Differentiation. 2011, 53(3):347-56. (#:co-first authors, *: corresponding author)

    11.   Wen L, Wei W, Gu W, Huang P, Ren X, Zhu Z, Lin S, Zhang B. Visualization of monoaminergic neurons and neurotoxicity of MPTP in live transgenic zebrafish. Developmental Biology 2008, 314 (1): 84-92.

    12.   Wen L, Liang D, Wu L, Cai F, Pan Q, Long Z, Dai H, Xia K, Xia J. Efficient protein expression from the endogenous RNA polymerase I promoter using a human ribosomal DNA targeting vector. Biochemical Biophysical Research Communication. 2008, 367 (4): 846-851.

    13.   Wen L#, Wei W#, Huang H#, Qi F, Dong W, Du J, Xue YL, Zheng NZ, Ren X, Huang P, Ren J, Gao W, Xiao A, Kawakami K, Zhu ZY, Zhang B, Lin S. Large-scale enhancer trapping in zebrafish using Tol2 transposon. 2006 International Zebrafish Development and Genetics Conference.(Abstract, #: co-first authors)