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葛颢
研究员

  • E-mail:haoge#pku.edu.cn
  • 办公电话:+86-10-62751674
    办公地点:北京大学综合科研楼生物动态光学成像中心311室
    邮件地址:北京市海淀区颐和园路5号北京大学综合科研楼生物动态光学成像中心311室,100871
    研究组主页:http://bicmr.pku.edu.cn/~gehao
  • 理学博士,北京大学,2008,数学
    理学学士,北京大学,2004,数学

    工作经历
  • 2011-现在,北京大学生物动态光学成像中心,研究员

    2011-现在,北京国际数学研究中心,副教授

    2010-2011,哈佛大学化学与生物化学系,访问学者

    2010-2011,复旦大学数学科学学院,副教授

    2008-2009,复旦大学数学科学学院,讲师

    主要研究方向
  • 非平衡态热力学和统计物理;单分子物理化学;生物数学;生物物理化学。 概率论与随机过程作为数学的一个重要分支,是伴随着十九世纪中叶到二十世纪初的统计力学发展并壮大起来的。而与此同时,该理论也已经广泛应用于物理化学的各个角落,并随着近些年来实验技术的突飞猛进而有越来越流行的趋势。我们希望通过深入研究现代科学中的随机数学模型,尝试研究和回答其他学科的基本问题,试图给出一些更深刻的更定量的结果。 该研究方向综合多学科的知识,涉及到数学、物理、化学以及生物,甚至涉及工程学上使用的信息论等等。
    获奖及荣誉
  • 2016,  NSFC优秀青年基金

    2016,  教育部长江学者奖励计划青年学者

    2010,全国优秀博士论文
    2009,中国数学会"家庆数学奖"(优秀博士论文奖)

    代表性论文及论著
  • 20.Zhao, Z.Q., Xie, X.S. and Ge, H.: Nonequilibrium Relaxation of Conformational Dynamics Facilitates Catalytic Reaction in an Elastic Network Model of T7 DNA Polymerase. J. Phys. Chem. B 120, 2869?2877 (2016)

    19.Ge, H. and Qian, H.: Mesoscopic kinetic basis of macroscopic chemical thermodynamics: A mathematical theory. Phys. Rev. E 94, 052150 (2016) 

    18.Ge, H., Qian, H. and Xie, X.S.:  Stochastic phenotype transition of a single cell in an intermediate region of gene state switching. Phys. Rev. Lett. 114, 078101 (2015)

    17. Chong, S.S., Chen, C.Y., Ge, H. and Xie, X.S.: Mechanism of transcriptional bursting in bacteria. Cell 158, 314–326 (2014)

    16. Ge, H.: Time reversibility and nonequilibrium thermodynamics of second-order stochastic processes. Phys. Rev. E 89, 022127 (2014)

    15. Kim, S., Broströmer, E., Xing, D., Jin, J.S., Chong, S.S., Ge, H., Wang, S.Y., Gu, C., Yang, L., Gao, Y.Q., Su, X.D., Sun, Y.J. & Xie, X.S.: Probing allostery through DNA. Science 339 816 (2013)

    14. Xu, X.L., Ge, H., Gu, C., Gao, Y. Q., Wang, S.Y., Thio, B., Hynes, J., Xie, X.S. and Cao, J.S.: Modeling spatial correlation of DNA deformation: DNA allostery in protein binding. J. Phys. Chem. B 117, 13378−13387 (2013) (co-first-author)
    13. Ge, H.: Multivariable fluctuation theorems in the steady-state cycle kinetics of single enzyme with competing substrates. J. Phys. A: Math. Theor. 45 215002 (2012) (Research highlighted)

    12. Ge, H. and Qian, H.: Landscapes of nongradient dynamics without detailed balance: stable limit cycles and multiple attractors. Chaos: An interdisciplinary journal of nonlinear science 22, 023140 (2012)

    11. Ge, H., Pressé, S., Ghosh, K. and Dill, K.: Markov processes follow from the principle of maximum caliber. J. Chem. Phys. 136, 064108 (2012) (highlighted by the journal)

    10. Ge, H., Qian, M. and Qian,H.: Stochastic theory of nonequilibrium steady states. Part II: Applications in chemical biophysics. Phys. Rep. 510, 87-118 (2012)

    9. Hao Ge, Hong Qian. Nonequilibrium phase transition in a mesoscoipic biochemical system: From stochastic to nonlinear dynamics and beyond. Journal of Royal Society Interface 2011, 8, 107-116.

    8. Hao Ge, Hong Qian. The physical origins of entropy production, free energy dissipation and their mathematical representations. Physical Review E 2010, 81, 051133.

    7. Hao Ge, Min Qian. Boolean network approach to negative feedback loops of the p53 pathways: Synchronized dynamics and stochastic limit cycles. Journal of Computational Biology 2009, 16, 119-132.

    6. Hao Ge. Extended forms of the second law for general time-dependent stochastic processes. Physical Review E 2009, 80, 021137.

    5. Hao Ge, Hong Qian. Thermodynamic limit of a nonequilibrium steady state: Maxwell-type construction for a bistable biochemical system. Physical Review Letters 2009, 103, 148103.

    4. Ge, H., Qian, H. and Qian, M.: Synchronized dynamics and nonequilibrium steady states in a yeast cell-cycle network. Mathematical Bioscience 2008, 211, 132-152.

    3. Hao Ge. Waiting cycle times and generalized Haldane equality in the steady-state cycle kinetics of single enzymes. Journal of Physical Chemistry B 2008, 112, 61-70.

    2. Hao Ge, Daquan Jiang. Generalized Jarzynskis equality of multidimensional inhomogeneous diffusion processes. Journal of Statistical Physics 2008, 131, 675-689.

    1. Hao Ge, Min Qian. Sensitivity amplification in the phosphorylation-dephosphorylation cycle: nonequilibrium steady states, chemical master equation and temporal cooperativity. Journal of Chemical Physics 2008, 129, 015104.