Sunney Xie
Cheung Kong Visiting Professor(PI)

  • E-mail:xie#chemistry.harvard.edu
  • Tel:+86-10-6274.4061 +1-617-496.9925
    Office:Rm. 301, Biodynamic Optical Imaging Center, Integrated Science Research Center, Peking University
    Mailing Address:Biodynamic Optical Imaging Center, Integrated Science Research Center, Peking University, Yiheyuan Rd., No. 5, Haidian District, Beijing, 100871
    Website:http://bernstein.harvard.edu/pages/AboutProfXie.html
  • Ph.D. , University of California at San Diego Chemistry, Chemistry, 1990
    B.S.  Peking University, Beijing, P. R. China, Chemistry, 1984

    Professional Experiences
  • 2016.8- Director, 

    2011-PI, PKU-Tsinghua Center for Life Sciences

    2010-Founder and Director, Biodynamic Optical Imaging Center, Peking University

    2010- Adjunct Professor of Chemistry, School of Chemistry and Molecular Engineering, Peking University

    2009- Cheung Kong Visiting Professor of Life Sciences, School of Life Sciences, Peking University

    2009 - Mallinckrodt Professor of Chemistry and Chemical Biology, Department of Chemistry and Chemical Biology, Harvard University

    1999 - 2008 Professor of Chemistry, Harvard University, Department of Chemistry and Chemical Biology

    1992 - 1998 Senior Research Scientist to Chief Scientist, Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory

    1990 - 1992 Postdoctoral Fellow, University of Chicago

    Research Interests
  • Scientific research of Xie Lab at BIOPIC mainly focus on three directions: 1) develop new single cell genome, transcriptome, epigenome sequencing methods and advance their applications in cancer and human reproductive biology; 2) manipulate and image single molecules in both in vitro and in vivo conditions; 3) develop non-invasive microscopy techniques and push forward their applications to cell biology and medical imaging.
    Awards and Honors
  • 2016   Ray Wu Award, Chinese Biological Investigators Society

    2015   Shizhang Bei Prize in Biophsyics, Chinese Biophysical Society

    2015 Albany Prize in Medicine Recipient

    2015 ACS Peter Debye Award in Physical Chemistry

    2014 Fellow of Optical Society of America

    2014 Humboldt Fellowship, Germany

    2013 NIH Director's Pioneer Award Recipient

    2013 Ellis R. Lippincott Award, Optical Society of America and Society for Applied Spectroscopy

    2012 Harrison Howe Award, Rochester Section of American Chemical Society

    2012 Fellow of the American Academy of Microbiology

    2012 Biophysical Society Founders Award

    2011 Elected to the National Academy of Sciences

    2010 Honorary Fellow of the Chinese Chemical Society


    Selected Publication
  • 22. Yan, Liying; Huang, Lei; Xu, Liya; Huang, Jin; Ma, Fei; Zhu, Xiaohui; Tang, Yaqiong; Liu, Mingshan; Lian, Ying; Liu, Ping; Li, Rong; Lu, Sijia; Tang, Fuchou; Qiao, Jie; Xie, X Sunney. "Live births after simultaneous avoidance of monogenic diseases and chromosome abnormality by next-generation sequencing with linkage analyses" PNAS 112(52), 15964-15969 (2015).

    21. Ni, Xiaohui; Zhuo, Minglei; Su, Zhe; Duan, Jianchun; Gao, Yan; Wang, Zhijie; Zong, Chenghang; Bai, Hua; Chapman, Alec R.; Zhao, Jun; Xu, Liya; An, Tongtong; Ma, Qi; Wang, Yuyan; Wu, Meina; Sun, Yu; Wang, Shuhang; Li, Zhenxiang; Yang, Xiaodan; Yong, Jun; Su, Xiao-Dong; Lu, Youyong; Bai, Fan; Xie, X. Sunney; Wang, Jie. "Reproducible copy number variation patterns among single circulating tumor cells of lung cancer patients" PNAS 110, 21083-21088 (2013).

    20,Sangjin Kim &, Erik Broströmer&, Dong Xing&, Jianshi Jin&, Shasha Chong, HaoGe, Siyuan Wang, Chan Gu, Lijiang Yang, Yi Qin Gao, Xiao-dong Su*, Yujie Sun*, X. SunneyXie*, Probing Allostery Through DNA. Science 2013, 339:816-819 (2013)

    19,Zong, Chenghang; Lu, Sijia; Chapman, Alec R.; Xie, X. Sunney. "Genome-Wide Detection of Single-Nucleotide and Copy-Number Variations of a Single Human Cell," Science 338, 1622-1626 (2012).

    18, Lu, Sijia; Zong, Chenghang; Fan, Wei; Yang, Mingyu; Li, Jinsen; Chapman, Alec R.; Zhu, Ping; Hu, Xuesong; Xu, Liya; Bai, Fan; Qiao, Jie; Tang, Fuchou; Li, Ruiqiang; Xie, X. Sunney. "Probing Meiotic Recombination and Aneuploidy of Single Sperm Cells by Whole-Genome Sequencing," Science 338, 1627-1630 (2012).
    17, Taniguchi, Yuichi; Choi, Paul J.; Li, Gene-Wei; Chen, Huiyi; Babu, Mohan; Hearn, Jeremy; Emili, Andrew; Xie, X. Sunney "Quantifying E. coli Proteome and Transcriptome with Single-Molecule Sensitivity in Single Cells" Science, 329, 533-538 (2010).
    16, Min, Wei; Lu, Sijia; Chong, Shasha; Roy, Rahul; Holtom, Gary R.; Xie, X. Sunney "Imaging chromophores with undetectable fluorescence by stimulated emission microscopy" Nature, 461, 1105-1109 (2009).
    15, Blainey, Paul C.; Luo, Guobin; Ko9u, S.C.; Mangel, Walter F.; Verdine, Gregory L.; Bagchi, Biman; Xie, X. Sunney "Nonspecifically bound proteins spin while diffusing along DNA" Nature Structural & Molecular Biology, 16, 1224-1229 (2009)
    14, Freudiger, Christian W.; Min, Wei; Saar, Brian G.; Lu, Sijia; Holtom, Gary R.; He, Chengwei, Tsai, Jason C.; Kang, Jing X.; Xie, X. Sunney "Label-Free Biomedical Imaging with High Sensitivity by Stimulated Raman Scattering Microscopy," Science, 322, 1857-1861 (2008)
    13, Choi, Paul J.; Cai, Long; Frieda, Kirsten; Xie, X. Sunney "A Stochastic Single-Molecule Event Triggers Phenotype Switching of a Bacterial Cell," Science, 322, 442-446 (2008).
    12, Elf, Johan; Li, Gene-Wei; Xie, X. Sunney "Probing Transcription Factor Dynamics at the Single-Molecule Level in a Living Cell," Science, 316, 1191-1194 (2007).
    11, Kim, Sangjin; Blainey, Paul C; Schroeder, Charles M; Xie, X. Sunney "Multiplexed single-molecule assay for enzymatic activity on flow-stretched DNA," Nature Methods, 4, 397-399 (2007).
    10, Lee, Jong-Bong; Hite, Richard K.; Hamdan, Samir M.; Xie, X. Sunney; Richardson, Charles C.; van Oijen, Antoine M. "DNA primase acts as a molecular brake in DNA replication," Nature, 439, 621-624 (2006).
    9, Xie, X. Sunney; Yu, Ji; Yang, Wei Yuan "Living Cells as Test Tubes," Science, 312, 228-230 (2006).
    8, Yu, Ji; Xiao, Jie; Ren, Xiaojia; Lao, Kaiqin; Xie, X. Sunney; "Probing Gene Expression in Live Cells, One Protein Molecule at a Time," Science, 311, 1600-1603 (2006).
    7, Cai, Long; Friedman, Nir; Xie, X. Sunney "Stochastic protein expression in individual cells at the single molecule level," Nature, 440, 358-362 (2006).
    6, English, Brian P.; Min, Wei; van Oijen, Antoine M.; Lee, Kang Taek; Luo, Guobin; Sun, Hongye; Cherayil, Binny J.; Kou, S.C.; Xie, X. Sunney "Ever-fluctuating single enzyme molecules: Michaelis-Menten equation revisited," Nat. Chem. Bio., 2, 87 (2006).
    5, Yang, Haw; Luo, Guobin; Karnchanaphanurach, Pallop; Louie, Tai-Man; Rech, Ivan; Cova, Sergio; Xun, Luying; Xie, X. Sunney "Protein conformational dynamics probed by single-molecule electron transfer," Science 302, 262 (2003).
    4, van Oijen, Atoine M. ; Blainey, Paul C. ; Crampton, Donald J. ; Richardson, Charles C. ; Ellenberger, Tom; Xie, X. Sunney "Single-Molecule Kinetics of l Exonuclease Reveal Base Dependence and Dynamic Disorder," Science 301, 1235 (2003).
    3, Lu, H. Peter, Xun, Luying; Xie, X. Sunney "Single Molecule Enzymatic Dynamics," Science 282, 1877 (1998).
    2, Lu, H. Peter; Xie, X. Sunney "Single-Molecule Spectral Fluctuations at Room Temperature," Nature 385, 143 (1997).
    1, Xie, X. Sunney; Dunn, Robert C. "Probing Single Molecule Dynamics," Science 265, 361 (1994). 

    For a full list, please check here.