Fuchou Tang
Assistant Professor (PI)

  • E-mail:tangfuchou#pku.edu.cn
  • Tel:+86-10-6275.5246
    Office:Rm. 309, Biodynamic Optical Imaging Center, Integrated Science Research Center, Peking University
    Mailing Address:Biodynamic Optical Imaging Center, Integrated Science Research Center, Peking University, Yiheyuan Rd., No. 5, Haidian District, Beijing, 100871
    Website:
  • Ph. D., Peking University, 2003, Biology
    B. S., Peking University, 1998, Biology

    Professional Experiences
  • 2015-present, Peking Unviersity-Tsinghua University Center for Life Sciences, Principle Investigator

    2010-present, BIOPIC, College of Life Sciences, Peking University, Principle Investigator

    2004-2010, Gurdon Institute, University of Cambridge, Postdoctoral Research Associate

    Research Interests
  • Stem cells have self-renewal ability and multi-lineage differentiation potential and are crucial for mammalian embryonic development and adult life. Dissecting the molecular mechanisms of stem cell regulation is important for understanding mammalian growth and development, and for its application of regeneration medicine for cure human diseases. Our lab focuses on the epigenetic mechanisms of self-renewal ability and pluripotency of mouse embryonic stem (ES) cells, embryonic germ (EG) cells and Epi-Stem cells (EpiSC). Through this, we want to understand the epigenetic regulation of mammalian early embryonic development and the global epigenetic reprogramming during the development of primordial germ cells (PGCs). We use single cell microRNA profiling assay and deep sequencing-based single cell RNA-Seq digital transcriptome analysis we recently developed, single cell genotyping, deep sequencing-based ChIP-Seq, micro-manipulation of mouse early embryos to analyze the epigenetic regulation of the dynamic gene expression network in mammalian pluripotent stem cells and early embryonic cells.
    Awards and Honors
    Selected Publication
  • 10. Wen L, Tang Fuchou*. Reconstructing Complex Tissues from Single-Cell Analyses. Cell 2014; 157: 771-773 (*: Corresponding author) (Preview).
    9. Wen L, Li X, Yan L, Tan Y, Li R, Zhao Y, Wang Y, Xie J, Zhang Y, Song C, Yu M, Liu X, Zhu P, Li X, Hou Y, Guo H, Wu X, He C*, Li R*, Tang Fuchou*, Qiao J*. Whole-genome analysis of 5-hydroxymethylcytosine and 5-methylcytosine at base resolution in the human brain. Genome Biology 2014; 15: R49 (*: Co-corresponding author).
    8. Hu X, Zhang L, Mao SQ, Li Z, Chen J, Zhang RR, Wu HP, Gao J, Guo F, Liu W, Xu GF, Dai HQ, Shi YG, Li X, Hu B, Tang Fuchou, Pei D, Xu GL. Tet and TDG Mediate DNA Demethylation Essential for Mesenchymal-to-Epithelial Transition in Somatic Cell Reprogramming. Cell Stem Cell 2014; 14: 512-522.
    7. Hou Y, Fan W, Yan L, Li R, Lian Y, Huang J, Li J, Xu L, Tang Fuchou*, Xie XS*, Qiao J*. Genome Analyses of Single Human Oocytes. Cell 2013; 155:1492-1506 (*: Co-corresponding author).
    6. Guo H, Zhu P, Wu X, Li X, Wen L, Tang Fuchou*. Single-cell methylome landscapes of mouse embryonic stem cells and early embryos analyzed using reduced representation bisulfite sequencing. Genome Research 2013; 23: 2126-2135 (*: corresponding author).
    5. Yan L, Yang M, Guo H, Yang L, Wu J, Li R, Liu P, Lian Y, Zheng X, Yan J, Huang J, Li M, Wu X, Wen L, Lao K, Li R*, Qiao J*, Tang Fuchou*. Single-cell RNA-Seq profiling of human preimplantation embryos and embryonic stem cells. Nature Structural & Molecular Biology 2013; 20: 1131-1139 (*: co-corresponding author).
    4. Gan H, Wen L, Liao S, Lin X, Ma T, Liu J, Song CX, Wang M, He C, Han C*, Tang Fuchou*. Dynamics of 5-hydroxymethylcytosine during mouse spermatogenesis. Nature Communications 2013; 4: 1995 (*: co-corresponding author).
    3. Tang Fuchou, Lao K, Surani MA. Development and applications of single-cell transcriptome analysis. Nature Methods 2011; 8: S6-S11 (Review).
    2. Tang Fuchou, Barbacioru C, Bao S, Lee C, Nordman E, Wang X, Lao K, Surani MA. Tracing the Derivation of Embryonic Stem Cells from the Inner Cell Mass by Single-Cell RNA-Seq Analysis. Cell Stem Cell 2010; 6: 468 - 478.
    1. Tang Fuchou*, Barbacioru C*, Wang Y, Nordman E, Lee C, Xu N, Wang X, Bodeau J, Tuch BB, Siddiqui A, Lao K, Surani MA. mRNA-Seq whole transcriptome analysis of a single cell. Nature Methods 2009; 6: 377 - 382 (*: co-first author).