Fuchou TANG
Assistant Professor (PI)

  • E-mail:tangfuchou#pku.edu.cn
  • Tel:+86-10-6275.5246
    Office:Rm. 309, Biodynamic Optical Imaging Center, Integrated Science Research Center, Peking University
    Mailing Address:Biodynamic Optical Imaging Center, Integrated Science Research Center, Peking University, Yiheyuan Rd., No. 5, Haidian District, Beijing, 100871
  • Ph. D., Peking University, 2003, Biology
    B. S., Peking University, 1998, Biology
    Professional Experiences
  • 2004-2010, Postdoctoral Research Associate, Gurdon Institute, University of Cambridge
    2010-present, Principle Investigator, BIOPIC, College of Life Sciences, Peking University
    Research Interests
  • Stem cells have self-renewal ability and multi-lineage differentiation potential and are crucial for mammalian embryonic development and adult life. Dissecting the molecular mechanisms of stem cell regulation is important for understanding mammalian growth and development, and for its application of regeneration medicine for cure human diseases. Our lab focuses on the epigenetic mechanisms of self-renewal ability and pluripotency of mouse embryonic stem (ES) cells, embryonic germ (EG) cells and Epi-Stem cells (EpiSC). Through this, we want to understand the epigenetic regulation of mammalian early embryonic development and the global epigenetic reprogramming during the development of primordial germ cells (PGCs). We use single cell microRNA profiling assay and deep sequencing-based single cell RNA-Seq digital transcriptome analysis we recently developed, single cell genotyping, deep sequencing-based ChIP-Seq, micro-manipulation of mouse early embryos to analyze the epigenetic regulation of the dynamic gene expression network in mammalian pluripotent stem cells and early embryonic cells.
    Awards and Honors
    Selected Publication
  • 1. Tang Fuchou, Lao K, Surani MA. Development and applications of single-cell transcriptome analysis. Nature Methods 2011; 8: S6-S11 (Review)
    2. Tang Fuchou, Barbacioru C, Bao S, Lee C, Nordman E, Wang X, Lao K, Surani MA. Tracing the Derivation of Embryonic Stem Cells from the Inner Cell Mass by Single-Cell RNA-Seq Analysis. Cell Stem Cell 2010; 6: 468 - 478.
    3. Bao S*, Tang Fuchou*, Li X, Hayashi K, Gillich A, Lao K, Surani MA. Epigenetic reversion of postimplantation epiblast to pluripotent embryonic stem cells. Nature 2009; 461: 1292 - 1295 (*: co-first author).
    4. Tang Fuchou*, Barbacioru C*, Wang Y, Nordman E, Lee C, Xu N, Wang X, Bodeau J, Tuch BB, Siddiqui A, Lao K, Surani MA. mRNA-Seq whole transcriptome analysis of a single cell. Nature Methods 2009; 6: 377 - 382 (*: co-first author).
    5. Tang Fuchou*, Kaneda M*, O'Carroll D, Hajkova P, Barton SC, Sun YA, Lee C, Tarakhovsky A, Lao K, Surani MA. Maternal microRNAs are essential for mouse zygotic development. Genes & Development 2007; 21: 644 - 648 (*: co-first author).