Fuchou Tang
Professor (PI)

  • E-mail:tangfuchou#pku.edu.cn
  • Tel:+86-10-6275.5246
    Office:Rm. 309, Biodynamic Optical Imaging Center, Integrated Science Research Center, Peking University
    Mailing Address:Biodynamic Optical Imaging Center, Integrated Science Research Center, Peking University, Yiheyuan Rd., No. 5, Haidian District, Beijing, 100871
  • Ph. D., Peking University, 2003, Biology
    B. S., Peking University, 1998, Biology

    Professional Experiences
  • 2015-present, Peking Unviersity-Tsinghua University Center for Life Sciences, Principle Investigator

    2010-present, BIOPIC, College of Life Sciences, Peking University, Principle Investigator

    2004-2010, Gurdon Institute, University of Cambridge, Postdoctoral Research Associate

    Research Interests
  • Stem cells have self-renewal ability and multi-lineage differentiation potential and are crucial for mammalian embryonic development and adult life. Dissecting the molecular mechanisms of stem cell regulation is important for understanding mammalian growth and development, and for its application of regeneration medicine for cure human diseases. Our lab focuses on the epigenetic mechanisms of self-renewal ability and pluripotency of mouse embryonic stem (ES) cells, embryonic germ (EG) cells and Epi-Stem cells (EpiSC). Through this, we want to understand the epigenetic regulation of mammalian early embryonic development and the global epigenetic reprogramming during the development of primordial germ cells (PGCs). We use single cell microRNA profiling assay and deep sequencing-based single cell RNA-Seq digital transcriptome analysis we recently developed, single cell genotyping, deep sequencing-based ChIP-Seq, micro-manipulation of mouse early embryos to analyze the epigenetic regulation of the dynamic gene expression network in mammalian pluripotent stem cells and early embryonic cells.
    Awards and Honors
  • 2016, NSFC, Distinguished Young Investigator Award

    2015, Guxiaocheng Lecture Award, Ray Wu Fouddation

    2015, "Accurate Deduction of Maternal Genome Information" Listed as Top 10 China’s Scientific Advances in 2014

    2013, NSFC, Excellent Young Investigator Award

    Selected Publication

  • 13. Zhou F, Li X, Wang W, Zhu P, Zhou J, He W, Ding M, Xiong F, Zheng X, Li Z, Ni Y, Mu X, Wen L, Cheng T, Lan Y, Yuan W*, Fuchou Tang*, Liu B*. Tracing haematopoietic stem cell formation at single-cell resolution. Nature, 533: 487-492 (2016) (*: 共同通讯作者).

    12. Fan X, Zhang X, Wu X, Guo H, Hu Y, Tang Fuchou*, Huang Y*. Single-cell RNA-seq transcriptome analysis of linear and circular RNAs in mouse preimplantation embryos. Genome Biology 16: 148 (2015) (*: 共同通讯作者).

    11. Guo H, Zhu P, Guo F, Li X, Wu X, Fan X, Wen L*, Tang Fuchou*. Profiling DNA methylome landscapes of mammalian cells with single-cell reduced-representation bisulfite sequencing. Nature Protocols 10: 645-659 (2015) (*: 共同通讯作者).

    10. Wen L*, Tang Fuchou*, How to catch rare cell types. Nature 2015; doi:10.1038/nature15204 (*: Co-corresponding authors) (Preview). 

    9. Guo F, Yan L, Guo H, Li L, Hu B, Zhao Y, Yong J, Hu Y, Wang X, Wei Y, Wang W, Li R, Yan J, Zhi X, Zhang Y, Jin H, Zhang W, Hou Y, Zhu P, Li J, Zhang L, Liu S, Ren Y, Zhu X, Wen L, Gao YQ, Tang Fuchou*, Qiao J*. The transcriptome and DNA methylome landscapes of human primordial germ cells. Cell 2015; 161: 1437-1452 (*: Co-corresponding authors). 

    8. Zhang W, Li J, Suzuki K, Qu J, Wang P, Zhou J, Liu X, Ren R, Xu X, Ocampo A, Yuan T, Yang J, Li Y, Shi L, Guan D, Pan H, Duan S, Ding Z, Li M, Yi F, Bai R, Wang Y, Chen C, Yang F, Li X, Wang Z, Aizawa E, Goebl A, Soligalla RD, Reddy P, Esteban CR, Tang Fuchou*, Liu GH*, Belmonte JC*. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging. Science 2015; 348: 1160-1163 (*: Co-corresponding authors). 

    7. Wen L*, Tang Fuchou*, Charting a Map through the Cellular Reprogramming Landscape. Cell Stem Cell 2015; 16: 215-216 (*: Co-corresponding authors) (Preview). 

    6. Guo H, Zhu P, Yan L, Li R, Hu B, Lian Y, Yan J, Ren X, Lin S, Li J, Jin X, Shi X, Liu P, Wang X, Wang W, Wei Y, Li X, Guo F, Wu X, Fan X, Yong J, Wen L, Xie SX, Tang Fuchou*, Qiao J*. The DNA methylation landscape of human early embryos. Nature 2014; 511: 606-610 (*: Co-corresponding authors). 

    5. Guo F, Li X, Liang D, Li T, Zhu P, Guo H, Wu X, Wen L, Gu TP, Hu B, Walsh CP, Li J*, Tang Fuchou*, Xu GL*. Active and Passive Demethylation of Male and Female Pronuclear DNA in the Mammalian Zygote. Cell Stem Cell 2014; 15: 447-458 (*: Co-corresponding authors). 

    4. Wen L, Tang Fuchou*, Reconstructing Complex Tissues from Single-Cell Analyses. Cell 2014; 157: 771-773 (*: Corresponding author). 

    3. Hou Y, Fan W, Yan L, Li R, Lian Y, Huang J, Li J, Xu L, Tang Fuchou*, Xie XS*, Qiao J*. Genome Analyses of Single Human Oocytes. Cell 2013; 155: 1492-1506 (*: Co-corresponding authors). 

    2. Guo H, Zhu P, Wu X, Li X, Wen L, Tang Fuchou*. Single-cell methylome landscapes of mouse embryonic stem cells and early embryos analyzed using reduced representation bisulfite sequencing. Genome Research 2013; 23: 2126-2135 (*: Corresponding author). 

    1. Yan L, Yang M, Guo H, Yang L, Wu J, Li R, Liu P, Lian Y, Zheng X, Yan J, Huang J, Li M, Wu X, Wen L, Lao K, Li R*, Qiao J*, Tang Fuchou*. Single-cell RNA-Seq profiling of human preimplantation embryos and embryonic stem cells. Nature Structural & Molecular Biology 2013; 20: 1131-1139 (*: Co-corresponding authors).