Hao Ge
Associate Professor (PI)

  • E-mail:haoge#pku.edu.cn
  • Tel:+86-010-62744085, 62751674
    Office:Biodynamic Optical Imaging Center Annex Building, Rm 159, Peking University, Beijing 100871
    Mailing Address:Beijing International Center for Mathematical Research, Peking University, Beijing 100871, China
  • Sc.D., Peking University, 2008, Mathematics
    B.S., Peking University, 2004, Mathematics

    Professional Experiences
  • 2011-present, Peking University, BIOPIC, Principal Investigator

    2011-present, Peking University, Beijing International Center for Mathematical Research, Associate Professor

    2010-2011, Harvard University, Department of Chemistry and Chemical Biology, Visiting Scholar

    2010-2011, Fudan University, School of Mathematical Sciences, Associate Professor

    2008-2009, Fudan University, School of Mathematical Sciences, Lecturer

    Research Interests
  • Nonequilibrium thermodynamics and statistical mechanics; Single-molecule physical chemistry; Mathematical biology; Biophysical chemistry Probability and stochastic process, as an important branch of mathematics, have already been widely applied in a lot of scientific fields, and become more and more popular due to recent development of advanced experimental techniques. We want to answer several fundamental questions in sciences, such as cell biology and statistical mechanics, through carefully studying their related stochastic models. It is a really interdisciplinary field, which involves mathematics, physics, chemistry, biology and even engineering.
    Awards and Honors
  • 2016, NSFC,Excellent Young Scholar Award

    2010, National Excellent Doctoral Dissertation in China
    2009, Nineth “Zhong Jiaqing” Mathematical Awards of the Chinese Mathematical Community (Prize for Doctorial dissertation)

    Selected Publication
  • 18.Ge, H., Qian, H. and Xie, X.S.:  Stochastic phenotype transition of a single cell in an intermediate region of gene state switching. Phys. Rev. Lett. 114, 078101 (2015)

    17. Chong, S.S., Chen, C.Y., Ge, H. and Xie, X.S.: Mechanism of transcriptional bursting in bacteria. Cell 158, 314–326 (2014)

    16. Ge, H.: Time reversibility and nonequilibrium thermodynamics of second-order stochastic processes. Phys. Rev. E 89, 022127 (2014)

    15. Kim, S., Broströmer, E., Xing, D., Jin, J.S., Chong, S.S., Ge, H., Wang, S.Y., Gu, C., Yang, L., Gao, Y.Q., Su, X.D., Sun, Y.J. & Xie, X.S.: Probing allostery through DNA. Science 339 816 (2013)

    14. Xu, X.L., Ge, H., Gu, C., Gao, Y. Q., Wang, S.Y., Thio, B., Hynes, J., Xie, X.S. and Cao, J.S.: Modeling spatial correlation of DNA deformation: DNA allostery in protein binding. J. Phys. Chem. B 117, 13378−13387 (2013) (co-first-author)
    13. Ge, H.: Multivariable fluctuation theorems in the steady-state cycle kinetics of single enzyme with competing substrates. J. Phys. A: Math. Theor. 45 215002 (2012) (Research highlighted)

    12. Ge, H. and Qian, H.: Landscapes of nongradient dynamics without detailed balance: stable limit cycles and multiple attractors. Chaos: An interdisciplinary journal of nonlinear science 22, 023140 (2012)

    11. Ge, H., Pressé, S., Ghosh, K. and Dill, K.: Markov processes follow from the principle of maximum caliber. J. Chem. Phys. 136, 064108 (2012) (highlighted by the journal)

    10. Ge, H., Qian, M. and Qian,H.: Stochastic theory of nonequilibrium steady states. Part II: Applications in chemical biophysics. Phys. Rep. 510, 87-118 (2012)

    9. Hao Ge, Hong Qian. Nonequilibrium phase transition in a mesoscoipic biochemical system: From stochastic to nonlinear dynamics and beyond. Journal of Royal Society Interface 2011, 8, 107-116.

    8. Hao Ge, Hong Qian. The physical origins of entropy production, free energy dissipation and their mathematical representations. Physical Review E 2010, 81, 051133.

    7. Hao Ge, Min Qian. Boolean network approach to negative feedback loops of the p53 pathways: Synchronized dynamics and stochastic limit cycles. Journal of Computational Biology 2009, 16, 119-132.

    6. Hao Ge. Extended forms of the second law for general time-dependent stochastic processes. Physical Review E 2009, 80, 021137.

    5. Hao Ge, Hong Qian. Thermodynamic limit of a nonequilibrium steady state: Maxwell-type construction for a bistable biochemical system. Physical Review Letters 2009, 103, 148103.

    4. Ge, H., Qian, H. and Qian, M.: Synchronized dynamics and nonequilibrium steady states in a yeast cell-cycle network. Mathematical Bioscience 2008, 211, 132-152.

    3. Hao Ge. Waiting cycle times and generalized Haldane equality in the steady-state cycle kinetics of single enzymes. Journal of Physical Chemistry B 2008, 112, 61-70.

    2. Hao Ge, Daquan Jiang. Generalized Jarzynskis equality of multidimensional inhomogeneous diffusion processes. Journal of Statistical Physics 2008, 131, 675-689.

    1. Hao Ge, Min Qian. Sensitivity amplification in the phosphorylation-dephosphorylation cycle: nonequilibrium steady states, chemical master equation and temporal cooperativity. Journal of Chemical Physics 2008, 129, 015104.