Xiaowei Zhuang
Visiting Professor (PI)

  • E-mail:zhuang#chemistry.harvard.edu
  • Tel:
    Office:Rm.328,Expreiment Building No.1,
    Mailing Address:Biodynamics Optical Imaging Center, Peking University, Beijing, 100871
  • 1997-2001 Chodorow Postdoctoral Fellow, Stanford University

    1991-1996 Ph.D., Physics, University of California, Berkeley

    1987-1991 B.S., Physics, University of Science and Technology of China

    Professional Experiences
  • 2013-presnt, BIOPIC, Peking University,Adjunct Professor

    2006-present, Department of Chemistry and Chemical Biology,Department of Physics, Harvard University, Professor

    2005-present, Howard Hughes Medical Institute, Investigator

    2005 -2006, Department of Chemistry and Chemical Biology,Department of Physics, Harvard University, Associate Professor

    2001-2005, Department of Chemistry and Chemical Biology, Department of Physics, Harvard University, Assistant Professor

    Research Interests
  • The Zhuang research lab works on the forefront of single-molecule biology and bioimaging, developing and applying advanced optical imaging techniques to study the behavior of individual biological molecules and molecular assemblies in vitro and in live cells. The current research is focused on two major directions: (1) Developing super-resolution optical microscopy that allows cell and tissue imaging with nanoscopic scale resolution and applying this technology to cell biology, neurobiology and microbiology, (2) investigating how biomolecules function, especially how proteins and nucleic acids interact, using single-molecule fluorescence imaging and spectroscopy
    Awards and Honors
  • 2013 Member, American Academy of Arts and Sciences
    2012 Member, National Academy of Sciences
    2012 Fellow, American Association of the Advancement of Science
    2012 Fellow, American Physical Society
    2011 Raymond & Beverly Sackler International Prize in Biophysics
    2010 Max Delbruck Prize in Biological Physics
    2008 HHMI collaborative Innovation Award
    2008 Coblentz Award
    2006 Pure Chemistry Award
    2005 Camille Dreyfus Teacher-Scholar Award
    2004 Sloan Research Fellowship
    2004 Technology Review Worlds Top 100 Young Innovators Award
    2003 MacArthur Fellowship
    2003 Packard Fellowship for Science and Engineering
    2003 CAREER award, National Science Foundation
    2003 Searle Scholar
    2003 Beckman Young Investigator Award
    2002 Young Investigator Award, Office of Naval Research
    2000 Individual National Research Service Award, National Institute of Health
    1997 Chodorow Postdoctoral Fellowship, Stanford University,

    Selected Publication
    • 10. Sebastian Deindl, William L. Hwang, Swetansu K. Hota, Timothy R. Blosser, Punit Prasad, Blaine Bartholomew, Xiaowei Zhuang. ISWI remodelers slide nucleosomes with coordinated multi-base-pair entry steps and single-base-pair exit steps. Cell 2013, 152(3), 442-452.

      9. Ke Xu, Guisheng Zhong, Xiaowei Zhuang. Actin, spectrin and associated proteins form a periodic cytoskeleton structure in axons. Science 2013, 339(6118), 452-456.

      8. W. Wang, G. Li, C. Chen, X. Xie, X. Zhuang, "Chromosome Organization by a Nucleoid Associated Protein", Science 333, 1445-1449 (2011)

      7. T. Blosser, J. Yang, M. Stone, G. Narlikar, X. Zhuang, "Dynamics of Nucleosome Remodeling by Individual ACF Complexes", Nature 462, 1022-1027 (2009)

      6. S. Liu, E. Abbondanzieri, J. W. Rausch, S. F. J. Le Grice, X. Zhuang, "Slide into action: dynamic shuttling of HIV reverse transcriptase on nucleic acid substrates", Science 322, 1092-1097 (2008)

      5. E. Abbondanzieri, G. Bokinsky, J. W. Rausch, J. X. Zhang, S. F. J. Le Grice, X. Zhuang, "Dynamic binding orientations direct activity of HIV reverse transcriptase", Nature 453, 184-189 (2008)

      4. B. Huang, W. Wang, M. Bates, X. Zhuang, "Three-dimensional Super-resolution Imaging by Stochastic Optical Reconstruction Microscopy", Science 319, 810-813 (2008)

      3. M. Bates, B. Huang, G. T. Dempsey, X. Zhuang, "Multicolor Super-Resolution Imaging with Photo-Switchable Fluorescent Probes", Science 317, 1749-1753 (2007)

      2. M. D. Stone, M. Mihalusova, C. M. O'Connor, R. Prathapam, K. Collins, X. Zhuang, "Stepwise protein-mediated RNA folding directs assembly of telomerase ribonucleoprotein", Nature 446, 458-461 (2007)

      1. M. J. Rust, M. Bates, X. Zhuang, "Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM)", Nature Methods 3, 793-795 (2006)