您的位置:首页 > 中心成员 > 中心教师

高歌
研究员

  • E-mail:gaog@pku.edu.cn
  • 办公电话:+86-10-62755206
    办公地点:北京大学王克桢楼306室
    邮件地址:
    研究组主页:
  • 2006,北京大学生物信息学,博士

 工作经历

  • 2019-至今,北京大学生物医学前沿创新中心,研究员

    2011-2018,北京大学生命科学学院,研究员

    2008-2011,北京大学生命科学学院,副研究员

     

 主要研究方向

  • 高歌课题组主要以生物信息学分析技术、方法与平台开发为基础,通过综合运用大数据与统计学习(statistical learning)等计算方法,整合高通量遗传学与功能基因组学数据,探索新表达调控因子的功能与演化及其对生物体新性状和新功能的贡献。

 获奖及荣誉

  • 2014,北京大学教学优秀奖

    2012,入选 首批青年拔尖人才支持计划

    2010,APBioNet Service Award

    2010,首届绿叶生物医药杰出青年学者奖

 代表性论文及论著

  • 生物学大数据的整合与挖掘

    1. Cheng S. J., Shi F. Y., Liu H., Ding Y., Jiang S., Liang N., Gao G.* 2017. Accurately annotate compound effects of genetic variants using a context-sensitive framework. Nucleic Acids Res. 45(10): e82. (Featured as “Highly Accessed”)

    2. Hou M., Tian F., Jiang S., Kong L., Yang D., Gao G.* 2016a. LocExpress: a web server for efficiently estimating expression of novel transcripts. BMC Genomics 17(13): 175-179. (Featured as Best Paper at InCoB’16)

    3. Hou M., Tang X., Tian F., Shi F., Liu F., Gao G.* 2016b. AnnoLnc: a web server for systematically annotating novel human lncRNAs. BMC Genomics 17(1): 931.

    4. Hu B., Jin J., Guo A. Y., Zhang H., Luo J., Gao G.* 2015. GSDS 2.0: an upgraded gene feature visualization server. Bioinformatics 31(8): 1296-1297. (Featured as ESI Highly Cited (Top 1%) Paper)

    5. Xiao A., Cheng Z., Kong L., Zhu Z., Lin S., Gao G.*, Zhang B.* 2014. CasOT: a genome-wide Cas9/gRNA off-target searching tool. Bioinformatics 30(8): 1180-1182. (Featured as ESI Highly Cited (Top 1%) Paper)

    6. Kong L., Wang J., Zhao S., Gu X., Luo J.*, Gao G.* 2012. ABrowse - a customizable next-generation genome browser framework. BMC Bioinformatics 13: 2. (Featured as “Highly Accessed”)

    7. Wang J., Kong L., Zhao S., Zhang H., Tang L., Li Z., Gu X., Luo J.*, Gao G.* 2011. Rice-Map: a new-generation rice genome browser. BMC Genomics 12: 165. (Featured as “Highly Accessed”)

    调控网络的功能与演化 

    8. Jin J., Tian F., Yang D. C., Meng Y. Q., Kong L., Luo J., Gao G.* 2017. PlantTFDB 4.0: toward a central hub for transcription factors and regulatory interactions in plants. Nucleic Acids Res 45(D1): D1040-D1045. (Featured as ESI Highly Cited (Top 1%) Paper)

    9. Jin J., He K., Tang X., Li Z., Lv L., Zhao Y., Luo J., Gao G.* 2015. An Arabidopsis Transcriptional Regulatory Map Reveals Distinct Functional and Evolutionary Features of Novel Transcription Factors. Mol Biol Evol 32(7): 1767-1773.

    10. Zhao Y., Tang L., Li Z., Jin J., Luo J., Gao G.* 2015. Identification and analysis of unitary loss of long-established protein-coding genes in Poaceae shows evidences for biased gene loss and putatively functional transcription of relics. BMC Evol Biol 15: 66. (Featured as “Very Good (being of special significance in its field)” by Faculty of 1000)

    11. Gao G., Vibranovski M. D., Zhang L., Li Z., Liu M., Zhang Y. E., Li X., Zhang W., Fan Q., VanKuren N. W., Long M., Wei L. 2014. A long-term demasculinization of X-linked intergenic noncoding RNAs in Drosophila melanogaster. Genome Res 24(4): 629-638.

    12. Jin J., Zhang H., Kong L., Gao G.*, Luo J.* 2014. PlantTFDB 3.0: a portal for the functional and evolutionary study of plant transcription factors. Nucleic Acids Res 42(1): D1182-1187. (Featured as ESI Highly Cited (Top 1%) Paper)

    13. Tang X., Hou M., Ding Y., Li Z., Ren L., Gao G.* 2013. Systematically profiling and annotating long intergenic non-coding RNAs in human embryonic stem cell. BMC Genomics 14(Suppl 5): S3. (Featured as “Highly Accessed”)

    14. Chen Z. X., Zhang Y. E., Vibranovski M., Luo J., Gao G.*, Long M.* 2011. Deficiency of X-linked inverted duplicates with male-biased expression and the underlying evolutionary mechanisms in the Drosophila genome. Mol Biol Evol 28(10): 2823-2832. 

    慕课教学

    15. Ding Y., Wang M., He Y., Ye A. Y., Yang X., Liu F., Meng Y., Gao G.*, Wei L.* 2014. `Bioinformatics: Introduction and Methods,` a Bilingual Massive Open Online Course (MOOC) as a New Example for Global Bioinformatics Education. PLoS Computational Biology 10(12): e1003955.

    部分合作论文

    1. Zhou Y., Wang P., Tian F., Gao G., Huang L., Wei W., Xie X. S. 2017. Painting a specific chromosome with CRISPR/Cas9 for live-cell imaging. Cell Res 27(2): 298-301.

    2. Feng S., Zhao Y., Xu Y., Ning S., Huo W., Hou M., Gao G., Ji J., Guo R.*, Xu D.* 2016. Ewing Tumor-associated Antigen 1 Interacts with Replication Protein A to Promote Restart of Stalled Replication Forks. J Biol Chem 291(42): 21956-21962.

    3. Xing M., Yang M., Huo W., Feng F., Wei L., Jiang W., Ning S., Yan Z., Li W., Wang Q., Hou M., Dong C., Guo R., Gao G., Ji J., Zha S., Lan L., Liang H., Xu D. 2015. Interactome analysis identifies a new paralogue of XRCC4 in non-homologous end joining DNA repair pathway. Nat Commun 6: 6233.

    4. Shu J., Wu C., Wu Y., Li Z., Shao S., Zhao W., Tang X., Yang H., Shen L., Zuo X., Yang W., Shi Y., Chi X., Zhang H., Gao G., Shu Y., Yuan K., He W., Tang C.*., Zhao Y., Deng HK.*. 2013. Induction of pluripotency in mouse somatic cells with lineage specifiers. Cell 153(5): 963-975.

    5. Yue R., Li H., Liu H., Li Y., Wei B., Gao G., Jin Y., Liu T., Wei L., Du J., Pei G.* 2012. Thrombin receptor regulates hematopoiesis and endothelial-to-hematopoietic transition. Dev Cell 22(5): 1092-1100.