HOME» PEOPLE» Xiaodong Su

Xiaodong Su
Cheung Kong Professor (PI)

  • E-mail:xdsu@pku.edu.cn
  • Tel:+86-10-62759743
    Office:Rm. 305, Biodynamic Optical Imaging Center, Integrated Science Research Center, Peking University
    Mailing Address:Biodynamic Optical Imaging Center, Integrated Science Research Center, Peking University, Yiheyuan Rd., No. 5, Haidian District, Beijing, 100871
  • Ph. D. Karolinska Institutet, 1994
    B. S. Peking University, Physics, 1985

    Professional Experiences

  • 2010-Present, Deputy Vice Director, Principle Investigator, Biodynamics Optical Imaging Center (BIOPIC), Peking University, China

    2004-Present, General-secretary, Chinese Crystallographic Society

    2003-Present, Associate Director, the National Laboratory of Protein Engineering and Plant Genetic Engineering, Peking University, China

    2003-Present,Cheung Kong Scholar, Professor of Biochemistry and Molecular Biology, School of Life Sciences, Peking University, China

    1998-2002, Assistant Professor and Docent, Center of Chemistry and Chemical Engineering, Lund University, Sweden
    Research Interests

  • Su lab has been working in the fields of structural biology and molecular biophysics for the last 20 years, the main activities have been: Structural, functional and evolutionary studies of bio-macromolecules by X-ray crystallographic, biochemical and biophysical methods, particularly work on macromolecules related to innate immunity and cancer; Rational design of drugs by structure/function-based methods; Utilizing and developing anomalous dispersion methods, particularly SAD methods and low-resolution ab initio phasing methods for X-ray crystallography; Novel approaches in protein crystallization. Currently, my group has also started to work on single molecule biophysics and NGS (next-generation sequencing) related technique developments.
    Awards and Honors

  • 2003, National Science Fund for Distinguished Young Scholars, National Natural Science Foundation of China
    2002, Cheung Kong Scholar, Ministry of Education, China

    Selected Publication

    28. Lian TF, Xu YP, Li LF and Su XD. Crystal Structure of Tetrameric Arabidopsis MYC2 Reveals the Mechanism of Enhanced Interaction with DNA. Cell Rep. 2017;19:1334-1342.

    27. Wang Y, Ning X, Gao P, Wu S, Sha M, Lv M, Zhou X, Gao J, Fang R, Meng G, Su X and Jiang Z. Inflammasome Activation Triggers Caspase-1-Mediated Cleavage of cGAS to Regulate Responses to DNA Virus Infection. Immunity. 2017;46:393-404.
    26. Liu M, Liu Y, Di J, Su Z, Yang H, Jiang B, Wang Z, Zhuang M, Bai F and Su X. Multi-region and single-cell sequencing reveal variable genomic heterogeneity in rectal cancer. BMC Cancer. 2017;17:787.
    25. Tao J, Zhang XW, Jin J, Du XX, Lian T, Yang J, Zhou X, Jiang Z and Su XD. Nonspecific DNA Binding of cGAS N Terminus Promotes cGAS Activation. J Immunol. 2017;198:3627-3636.
    24. Li X, Nai S, Ding Y, Geng Q, Zhu B, Yu K, Zhu W-G, Dong M-Q, Su X-D, Xu X and Li J. Polo-like kinase 1 (PLK1)-dependent phosphorylation of methylenetetrahydrofolate reductase (MTHFR) regulates replication via histone methylation. Cell Cycle. 2017;16:1933-1942.
    23. Che X, Du XX, Cai X, Zhang J, Xie WJ, Long Z, Ye ZY, Zhang H, Yang L, Su XD and Gao YQ. Single Mutations Reshape the Structural Correlation Network of the DMXAA-Human STING Complex. J Phys Chem B. 2017;121:2073-2082.
    22. Da L-T, E C, Shuai Y, Wu S, Su X-D and Yu J. T7 RNA polymerase translocation is facilitated by a helix opening on the fingers domain that may also prevent backtracking. Nucleic Acids Research. 2017;45:7909-7921.

    21. Sangjin Kim, Erik Broströmer, Dong Xing, Jianshi Jin, Shasha Chong, Hao Ge, Siyuan Wang, Gu C, Yang L, Gao YQ, Xiao-dong Su*, Yujie Sun* & X. Sunney Xie* “Probing Allostery Through DNA” (2013) Science. 2013 Feb 15;339(6121):816-9. doi: 10.1126/science.1229223.
    20. Wang Z, Wu Y, Li L, Su XD “Intermolecular recognition revealed by the complex structure of human CLOCK-BMAL1 basic helix-loop-helix domains with E-box DNA.(2013) Cell Research. 2013 Feb; 23(2):213-24. doi: 10.1038/cr.2012.170. Epub 2012 Dec 11.
    19. Yi-He Huang, Xiang-Yu Liu, Xiao-Xia Du, Zheng-Fan Jiang & Xiao-Dong Su* “The Structural Basis for the Sensing and Binding of Cyclic di-GMP by STING” (2012) Nature Structural & Molecular Biology, 2012 Jun 24;19(7):728-30. doi: 10.1038/nsmb.2333
    18, Cao Q, Wang XJ, Liu CW, Liu DF, Li LF, Gao YQ, Su XD.Inhibitory mechanism of caspase-6 phosphorylation revealed by crystal structures, molecular dynamics (MD) simulations and biochemical assays.J Biol Chem. 2012 Mar 20. [Epub ahead of print]
    17, Wang KT, Desmolaize B, Nan J, Zhang XW, Li LF, Douthwaite S, Su XD.Structure of the bifunctional methyltransferase YcbY (RlmKL) that adds the m7G2069 and m2G2445 modifications in Escherichia coli 23S rRNA. Nucleic Acids Res. 2012 Feb 22. [Epub ahead of print]
    16, Xiao-Jun Wang, Xiang Liu, Kai-tuo Wang, Wei Mi, Yan Zhang, Lanfen LI, Andrea C, LeBlance, Xiao-Dong Su “Crystal structures of human caspase-6 reveal a novel intramolecular cleavage self-activation mechanism” (2010) EMBO Reports 11(11):841-7. Epub 2010 Oct 1.
    15, 苏晓东,Anders Liljas “核糖体晶体结构的研究历程 — 记2009年诺贝尔化学奖”(The story of ribosome structure:the Nobel Prize in Chemistry 2009) by Su Xiao Dong,LILJAS Anders.
    14, Nan B, Liu X, Zhou Y, Liu J, Zhang L, Wen J, Zhang X, Su XD, Wang YP “From Signal Perception to Signal Transduction: Ligand-Induced Dimeric Switch of DctB Sensory Domain in Solution” Molecular Microbiology (2010) 2010 Feb 10. [Epub ahead of print]
    13, Nan J, Brostromer E, Liu XY, Kristensen O, Su XD “Bioinformatics and structural characterization of a hypothetical protein from Streptococcus mutans: implication of antibiotic resistance. PLoS One. (2009) Oct 2;4(10):e7245.
    12, Jian Lei, Lan-Fen Li, Xiao-Dong Su “Crystal structures of phosphotransferase system enzymes PtxB (IIB(Asc)) and PtxA (IIA(Asc)) from Streptococcus mutans.” (2009) J Mol Biol. 2009 Feb 20; 386(2):465-75. Epub 2008 Dec 25.
    11, Cong Liu, Dan Li, Lan-Fen Li, Xiao-Dong Su “Ring-Opening Mechanism Revealed by Crystal Structures of NagB and Its ES Intermediate Complex” (2008) J Mol Biol. 379 (1):73-81
    10, Yanfeng Zhou, Beiyan Nan, Jie Nan, Qingjun Ma, Santosh Panjikar, Yuhe Liang, Yiping Wang and Xiao-Dong Su “C4-dicarboxylates sensing mechanism revealed by the crystal structures of DctB sensor domain.” (2008) J Mol Biol. 383 (1):49-61. Epub 2008 Aug 12
    9, Ming-Rui Duan, Jie Nan, Yu-He Liang, Peng Mao, Lu Lu, Luhua Lai, *Yi Li, and *Xiao-Dong Su, “DNA Binding Mechanism Revealed by High Resolution Crystal Structure of Arabidopsis thaliana WRKY1 Protein” Nucleic acid research (2007) 35(4):1145-54
    8, Su XD, Liang Y, Li L, Nan J, Brostromer E, Liu P, Dong Y, Xian D. “ A large-scale, high-efficiency and low-cost platform for structural genomics studies” Acta Crystallogr D Biol Crystallogr. (2006) 62(8):843-51
    7, Yu Y, Liang YH, Brostromer E, Quan JM, Panjikar S, Dong YH, Su XD. “A catalytic mechanism revealed by the crystal structures of the imidazolonepropionase from Bacillus subtilis”. J Biol Chem. (2006) 281(48):36929-36
    6, Marcia Alvarez-Fernandez, Yuhe Liang, Magnus Abrahamson and Xiao-Dong Su. “Crystal structure of human cystatin D, a cysteine peptidase inhibitor with restricted inhibition profile”, (2005) J. Biol. Chem. 280:18221-18228.
    5, Hui Ren, Liya Wang, Matthew Bennett, Yuhe Liang, Xiaofeng Zheng, Fei Lu, Lanfen Li, Jie Nan, Ming Luo, Staffan Eriksson, Chuanmao Zhang, and Xiao-Dong Su “The Crystal Structure of human Adenylate Kinase 6: An Adenylate Kinase Localized to the Cell Nucleus” (2005) Proc. Natl. Acad. Sci. USA (PNAS) 102:303-308
    4, Selmer, M; and Su, X-D;”Crystal structure of an mRNA binding fragment of Moorella thermoacetica SelB” (2002) EMBO J. 21 (15) 4145-53
    3, Bennett M; Guan, Z; Laurberg M and SU, X-D, “Bacillus subtillis arsenate reductase is structurally and functionally similar to low- molecular-weight protein tyrosine phosphatases” (2001) Proc. Natl. Acad. Sci, USA (PNAS) 98 13577-13582.
    2, Su, X-D; Gastinel, LN; Vaugh, DE; Faye, I; Poon,P & Bjorkman, PJ. “Crystall structure of hemolin: A horseshoe shape with implications for hemophilic adhesion” (1998) Science 281 991-995.
    1, Su, X-D; Taddei, N; Stefani, M; Ranponi, G & Nordlund, P “The crystal structure of a lowmolecular-weight phosphotyrosine protein phosphatase”(1994) Nature 370 575-578