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Lu Wen
Research Scientist

  • E-mail:wenlu@pku.edu.cn
  • Tel:+86-10-6275.5246
    Mailing Address:Biodynamic Optical Imaging Center, Peking University, Beijing, China, 100871
  • Ph.D., Genetics, National Laboratory of Medical Genetics of China, Central South University, Changsha, 2004
    M.S., Neurosurgery, Xiangya School of Medicine, Central South University, Changsha, 2000
    B.S., Medical Science, Xiangya School of Medicine, Central South University, Changsha, 2000 (a combined B.A.-M.S. training program)

    Professional Experiences

  • 2005-2008,Postdoctal Research Fellow, College of Life Sciences, Peking University

    2009-2010,Lecturer, College of Life Sciences, Sun Yat-sen University

    2011-2016,Research Associate, BIOPIC, College of Life Sciences, Peking University

    2017-present, Research Scientist, BIOPIC, College of Life Sciences, Peking University
    Research Interests

  • Single cell genomics and epigenomics
    Awards and Honors

    Selected Publication

    • 1.     Wen L* and Tang F*. Single-cell sequencing in stem cell biology. Genome Biology, 2016, 17:71. (Review, *: co-corresponding authors)

    • 2.     Wen L#, Li J#, Guo H#, Liu X#, Zheng S, Wen L, Li J, Guo H, Liu X, Zheng S, Zhang D, Zhu W, Qu J, Guo L, Du D, Jin X, Zhang Y, Gao Y, Shen J, Ge H, Tang F, Huang Y, Peng J. Genome-scale detection of hypermethylated CpG islands in circulating cell-free DNA of hepatocellular carcinoma patients. Cell Research, 2015 (25): 1250-1264. (#:co-first authors)

    • 3.     Guo H, Zhu P, Guo F, Li XL, Wu X, Fan X, Wen L*, Tang F*. Profiling DNA methylome landscapes of mammalian cells with single-cell reduced-representation bisulfite sequencing. Nature Protocol, 2015(5): 645-59. (*:co-corresponding authors) 

    • 4.     Wen L*, Tang F*. How to catch rare cell types. Nature, 2015, 525(7568):197-8. (Preview, Nature 2015 Editors' choice, *: co-corresponding authors)

    • 5.     Wen L*, Tang F*. Charting a map through the cellular reprogramming landscape. Cell Stem Cell. 2015 Mar 5;16(3):215-6. (Preview, *: co-corresponding authors)

    • 6.     Wen L#, Li X#, Yan L#, Tan Y#, Li R, Zhao Y, Wang Y, Xie J, Zhang Y, Song C, Yu M, Liu X, Zhu P, Li X, Hou Y, Guo H, Wu X, He C, Li R, Tang F, Qiao J. Whole-genome analysis of 5-hydroxymethylcytosine and 5-methylcytosine at base resolution in the human brain. Genome Biology. 2014, 15(3):R49. (#:co-first authors)

    • 7.     Wen L and Tang F. Reconstructing complex tissues from single-cell analyses. Cell, 2014(157): 771-773. (Preview)

    • 8.     Wen L* and Tang F. Genomic distribution and possible functions of DNA hydroxymethylation in the brain. Genomics. 2014, 104(5): 341–346. (Review, *: corresponding author)

    • 9.     Gan H#, Wen L#, Liao S#, Lin X, Ma T, Liu J, Song CX, Wang M, He C, Han C, Tang F. Dynamics of 5-hydroxymethylcytosine during mouse spermatogenesis. Nature Communication. 2013 Jun 13; 4:1995. (#:co-first authors)

    • 10.   Lan X#, Wen L#*, Li K, Liu X, Luo B, Chen F, Xie D, Kung H. Comparative analysis of duplicated sox21 genes in zebrafish. Development Growth Differentiation. 2011, 53(3):347-56. (#:co-first authors, *: corresponding author)

    • 11.   Wen L, Wei W, Gu W, Huang P, Ren X, Zhu Z, Lin S, Zhang B. Visualization of monoaminergic neurons and neurotoxicity of MPTP in live transgenic zebrafish. Developmental Biology 2008, 314 (1): 84-92.

    • 12.   Wen L, Liang D, Wu L, Cai F, Pan Q, Long Z, Dai H, Xia K, Xia J. Efficient protein expression from the endogenous RNA polymerase I promoter using a human ribosomal DNA targeting vector. Biochemical Biophysical Research Communication. 2008, 367 (4): 846-851.

    • 13.   Wen L#, Wei W#, Huang H#, Qi F, Dong W, Du J, Xue YL, Zheng NZ, Ren X, Huang P, Ren J, Gao W, Xiao A, Kawakami K, Zhu ZY, Zhang B, Lin S. Large-scale enhancer trapping in zebrafish using Tol2 transposon. 2006 International Zebrafish Development and Genetics Conference.(Abstract, #: co-first authors)