首页» 中心PI» 赵新生
联系方式

E-mail:zhaoxs@pku.edu.cn
办公地点:北京大学综合科研楼332室
邮件地址:北京市海淀区颐和园路5号北京大学综合科研楼,100871

研究组主页:http://www.chem.pku.edu.cn/zhaoxs/

赵新生
BIOPIC 研究员
个人履历

2010-现在,北京大学生物医学前沿创新中心研究员

2000-现在,北京大学化学与分子工程学院长江特聘教授

1992-2000,北京大学化学与分子工程学院,教授

1990-1992,北京大学化学系,副教授

1989-1990,美国麻省理工学院,博士后

1984-1990,北京大学化学系,讲师

1988,美国加州大学伯克利分校,哲学博士

1984,北京大学,理学硕士

1982,北京大学,理学学士

主要研究方向

主要研究兴趣是以单分子探测技术为主研究生物分子反应,特别是酶对核酸进行化学修饰和细菌对外膜蛋白进行保护和质量控制过程的微观动力学机理。

代表性论文及论著
  1. Sijia Peng, Xiaowei Wang, Lu Zhang*, Shanshan He, Xin Sheng Zhao*, Xuhui Huang*, Chunlai Chen*, Proc. Natl. Acad. Sci. U.S.A. 2020, 117, 21889–21895. Target search and recognition mechanisms of glycosylase AlkD revealed by scanning FRET-FCS and Markov State Models.
  2. Chen Yang, Sijia Peng, Chunlai Chen, Xin Sheng Zhao*, Biochem. J. 2020, 477, 2949–2965. Molecular mechanism of networking among DegP, Skp and SurA in periplasm for biogenesis of outer membrane proteins.
  3. Chenhui He, Sichen Pan, Geng Li, Xin Sheng Zhao*, Sci. China Chem. 2020, 63, 1142–1152. Molecular mechanism of SurA’s chaperoning function to outer membrane proteins revealed by purification-after-crosslinking single-molecule FRET.
  4. 赵新生,蒋鸿,《中级物理化学》,北京大学出版社,第2版,北京 2019
  5. Geng Li, Chenhui He, Peixuan Bu, Huimin Bi, Sichen Pan, Ronghua Sun, Xin Sheng Zhao*, ACS Chem. Biol. 2018, 13, 1082-1089. Single-Molecule Detection Reveals Different Roles of Skp and SurA as Chaperones.
  6. Lingyi Meng, Shanshan He, Xin Sheng Zhao*, J. Phys. Chem. B 2017, 121, 11262-11272. Determination of Equilibrium Constant and Relative Brightness in FRET-FCS by Including the Third-Order Correlations.
  7. Peng Wang, Lijiang Yang, Yi Qin Gao*, Xin Sheng Zhao*, Nucleic Acids Res. 2015, 43, 7207-7216. Accurate Placement of Substrate RNA by Gar1 in H/ACA RNA-guided Pseudouridylation.
  8. Yandong Yin, Lijiang Yang, Guanqun Zheng, Chan Gu, Chengqi Yi, Chuan He, Yi Qin Gao*, and Xin Sheng Zhao*, Proc. Natl. Acad. Sci. U.S.A. 2014, 111, 8043 – 8048. Dynamics of spontaneous flipping of a mismatched base in DNA duplex.