Date: 30 August 2012, Thursday

Time: 9:00-10:30am

Venue: Biopic, seminar room

Attendees:

BioNano Genomics:

Erik Holmlin, CEO

Han Cao, Founder and CSO

Garth Monroe, CFO

Todd Dickinson, VP Product Development & Marketing

AGENDA

9:00am Brief BioNano Company/Technology overview (Todd & Han)

9:30 Open Discussion

10:30 Adjourn

Abstract:

The IrysTM System: a new single molecule platform for mapping genomes based on nanochannel arrays

Despite significant advances in shotgun sequencing technology, de novo genome assemblies using only short read data are generally incomplete due to the complexity found in large genomes. This complexity, consisting mainly of large duplications and repetitive regions, hinders sequence assembly and subsequent comparative analysis. We present a single molecule genome analysis system based on a nanochannel array technology that resolves these sequence ambiguities. This technology provides high throughput sequence motif maps of single molecule fragments hundreds of kilobases in size. Capitalizing on the information encoded in the extremely long single molecule maps, assembly algorithms unique to this format deliver high-resolution whole-genome sequence motif maps.< SPAN style="mso-spacerun: yes"> Parallel assembly by shotgun sequencing and sequence motif mapping offers a multi-scale pathway for whole genome de novo assembly solving many of the ambiguities inherent in using short read assembly alone.