2019-Present, Principal Investigator, Beijing Advanced Innovation Center for Genomics

2019-Present, Principal Investigator, Biomedical Pioneering Innovation Center, Peking University

2019-Present, Principal Investigator, Peking-Tsinghua Center for Life Sciences

2017-2019, Postdoctoral Researcher, University of California, Berkeley

2012-2017, Research Specialist, Janelia Research Campus of HHMI

Deng's group will focuse on the regulation mechanisms of transcription and chromatin, and their dynamics at single molecular level.

1. Niu D, Deng W*. Nucleosomes as active platforms for pioneer factor action. Molecular Cell 86, no. 13 (2026): 2443–45. 

2. Wang Z, Liu Y, Wang B, Liu X, Deng W^*. Single-molecule localization and diffusivity microscopy reveals dynamic biomolecular organization in living cells[J]. Nature Methods, 2026: 1-13.

3. Wang Z, Wang B, Niu D, Yin C, Bi Y, Cattoglio C, Loh M, Lavis L, Ge H, Deng W^*. Mesoscale chromatin confinement facilitates target search of pioneer transcription factors in live cells. Nature Structural & Molecular Biology, 2025, 32(1): 125-136.

4. Zhang J, Zhang K, Wang K, Wang B, Zhu S, Qian H, Ma Y, Zhang M, Liu T, Chen P, Shen Y, Fu Y, Fang S, Zhang X, Zou P, Deng W, Mu Y, Chen Z. A palette of bridged bicycle-strengthened fluorophores. Nature Methods, 2025, 22(6): 1276-1287.

5. Ling J, Zhang Y, Hei Y, Kompa, J. Yang C, Wang B, Zhang J, Du J, Rudi T, Zhang K, Sun J, Wang W, Fabritz S, Li Y, Deng W, Zou P, Chen C, Chen Z. Thioether editing generally increases the photostability of rhodamine dyes on self-labeling tags. Proceedings of the National Academy of Sciences, 2025, 122(30): e2426354122.

6. Han X, Xing L, Hong Y, Zhang X, Hao B, Lu J, Huang M, Wang Z, Ma S, Zhan G, Li T, Hao X, Tao Y, Li G, Zhou S, Zheng Z, Shao W, Zeng Y, Ma D, Zhang W, Xie Z, Deng H, Yan J, Deng W, Shen X. Nuclear RNA homeostasis promotes systems-level coordination of cell fate and senescence. Cell Stem Cell, 2024, 31(5): 694-716.e11.

7. Wang Z, Deng W^*. Dynamic transcription regulation at the single-molecule level. Developmental Biology, 2022, 482: 67-81.

8. Wang H, Li B, Zuo L, Wang B, Yan Y, Tian K, Zhou R, Wang C, Chen X, Jiang Y, Zheng H, Qin F, Zhang B, Yu Y, Liu CP, Xu Y, Gao J, Qi Z, Deng W, Ji X. The transcriptional coactivator RUVBL2 regulates Pol II clustering with diverse transcription factors. Nat Communications 2022;13(1):5703.

9. W. Deng^#, X. Shi, R. Tjian, T. E. E. Lionnet, and R. H. Singer#, CASFISH: CRISPR/Cas9-mediated in situ labeling of genomic loci in fixed cells. Proceedings of the National Academy of Sciences 112, 11870-11875 (2015).

10. S. C. Knight, L. Xie, W. Deng, B. Guglielmi, L. B. Witkowsky, L. Bosanac, E. T. Zhang, M. E. Beheiry, J.-B. Masson, M. Dahan, and Z. Liu, Dynamics of CRISPR-Cas9 genome interrogation in living cells. Science 350, 823-827 (2015).

11. W. Deng^#, J. W. Rupon#, I. Krivega, L. Breda, I. Motta, K. S. Jahn, A. Reik, P. D. Gregory, S. Rivella, A. Dean, and G. A. Blobel, Reactivation of developmentally silenced globin genes by forced chromatin looping, Cell 158, 849-860 (2014).

12. W. Deng^#, J. Lee, H. Wang, J. Miller, A. Reik, P. D. Gregory, A. Dean, and G. A. Blobel, Controlling long-range genomic interactions at a native locus by targeted tethering of a looping factor. Cell 149, 1233-1244 (2012).

13. T. Tripic#, W. Deng^#, Y. Cheng, Y. Zhang, C. R. Vakoc, G. D. Gregory, R. C. Hardison, G. A. Blobel, SCL and associated proteins distinguish active from repressive GATA transcription factor complexes. Blood 113, 2191–2201 (2009).