Add:Rm. 305, Biomedical Pioneering Innovation Center, Integrated Science Research Center No.2,Peking University

Lab Web:

Xiao-dong Su
BIOPIC PI, Deputy Director

2010-Present, Deputy Director, Principle Investigator, Biodynamics Optical Imaging Center (BIOPIC), Peking University, China

2004-Present, General-secretary, Chinese Crystallographic Society

2003-Present, Associate Director, the National Laboratory of Protein Engineering and Plant Genetic Engineering, Peking University, China

2003-PresentCheung Kong Scholar, Professor of Biochemistry and Molecular Biology, School of Life Sciences, Peking University, China

1998-2002 Assistant Professor and Docent, Center of Chemistry and Chemical Engineering, Lund University, Sweden

1994Ph. D. Karolinska Institutet

1985B. S. Peking University, Physics

Research Interests

X-ray Crystallography; Protein Structure and Protein Chemistry; Single Molecule Biophysics; Enzymology; Molecular biology; Drug design; Protein Engineering.

Awards and Honors

2003, National Science Fund for Distinguished Young Scholars, National Natural Science Foundation of China


Selected Publication

1. H Xu, B Wang, TN Zhao, ZT Liang, TB Peng, XH Song, JJ Wu, YC Wang, XD Su* Structure-based analyses of neutralization antibodies interacting with naturally occurring SARS-CoV-2 RBD variants”. Cell Research (2021) 31 (10), 1126-1129.

2. Shuo Du, Yunlong Cao, Qinyu Zhu, Pin Yu, …… X Sunney Xie*, Xiao-dong Su*, Junyu Xiao*, Chuan Qin*. “Structurally resolved SARS-CoV-2 antibody shows high efficacy in severely infected hamsters and provides a potent cocktail pairing strategy”. Cell (2020) 183:1-11.

3. K Yu, Y Hu, F Wu, Q Guo, Z Qian, W Hu, J Chen, K Wang, X Fan, X Wu, JEJ Rasko, X Fan, A Iavarone*, T Jiang*, F Tang*, XD Su*. “Surveying brain tumor heterogeneity by single-cell RNA sequencing of multi-sector biopsies”. National Science Review (2020) 7:1306-18.

4. Xu YP, Xu H, Wang B, Su XD*. “Crystal structures of N-terminal WRKY transcription factors and DNA complexes”. Protein& Cell (2020) 11(3):208-213.

5. Lian TF, Xu YP, Li L, Su XD*. “Crystal Structure of tetrameric Arabidopsis MYC2 reveals the mechanism of enhanced interaction with DNA”. Cell Reports (2017) 19(7):1334-1342.

6. Gao J, Tao J, Liang W, Zhao M, Du X, Cui S, Duan H, Kan B, Su XD*, Jiang Z*. “Identification and characterization of phosphodiesterases that specifically degrade 3'3'-cyclic GMP-AMP”. Cell Res (2015) 25(5):539-50.

7. Bao ZS, Chen HM, Yang MY, Zhang CB, Yu K, Ye WL, Hu BQ, Yan W, ......, You YP, Fan XL, Li RQ, Su XD*, Chen CC*, Jiang T*. “RNA-Seq of 272 gliomas revealed a novel, recurrent PTPRZ-MET fusion transcript in secondary glioblastomas”. Genome Research (2014) 24(11):1765-73.

8. Kim S, Broströmer E, Xing D, Jin JS, Chong S, Ge H, Wang S, Gu C, Yang L, Gao YQ, Su XD*, Sun Y* & X. Xie XS*. “Probing Allostery Through DNA”. Science (2013) 339(6121):816-9.

9. Wang Z, Wu Y, Li L, Su XD*. “Intermolecular recognition revealed by the complex structure of human CLOCK-BMAL1 basic helix-loop-helix domains with E-box DNA”. Cell Research (2013) 23(2):213-24.