Add:Rm. 205, Biomedical Pioneering Innovation Center, Integrated Science Research Center No.2,Peking University

Lab Web:

Wensheng Wei
Professor (PI)

2019–Present, Professor (tenured), School of Life Sciences (SLS)

2018–Present, Director, Peking University Genome Editing Research Center

2016–Present, Investigator, Beijing Advanced Innovation Center for Genomics (ICG), Peking University

2015–Present, Investigator, Peking-Tsinghua Center for Life Sciences (CLS), Peking University

2014–Present, Investigator, Biomedical Pioneering Innovation Center (BIOPIC), Peking University

2016–Present, Investigator/Associate Professor (tenured), School of Life Sciences (SLS), Peking University

2007–2015, Investigator/Assistant Professor, School of Life Sciences (SLS), Peking University

2005–2007, Research Associate, Department of Genetics, Stanford University School of Medicine

1999–2004, Postdoctoral fellow in Genetics, Stanford University School of Medicine Mentor: Prof. Stanley N. Cohen

19951999, Ph.D. in Genetics, Michigan State University, East Lansing, USA

19871991, B.S. in Biochemistry, Peking University, China

Research Interests

The research of Wei group is mainly focused on the development of eukaryotic gene editing tools and novel nucleic acid therapeutics, with the emphasis on the high-throughput functional genomics and gene therapy. The combination of forward and reverse genetic means is employed, often in a high-throughput fashion, for the understanding of the molecular mechanisms underlying human diseases, including cancer and infection.

Awards and Honors

2019,BI Investigator Award, 2019

2019,Weiming Outstanding Researcher Award

2018,Beijing Science & Technology Award (Third grade)

2018,China Ministry of Science and Technology Innovation Talent Promotion Plan: Technology Innovation and Entrepreneurship

2018,Peking University Teaching Award

2016,China Patent Award

2016,Tan Jiazhen Life Science Award

2015,Scientific Chinese Man of the Year

2015,Zheng Changxue Teaching Award

2014,Bayer Investigator Award

2014,Roche Chinese Young Investigator Award

2012,Peking University Dongbao Fellowship

2010,Most popular teacher of School of Life Sciences

Selected Publication​
  1. Qu L, Yi Z, Shen Y, Lin L, Chen F, Xu Y, Wu Z, Tang H, Zhang X, Tian F, Wang C, Xiao X, Dong X, Guo L, Lu S, Yang C, Tang C, Yang Y, Yu W, Wang, J, Zhou Y, Huang Q, Yisimayi A, Liu S, Huang WJ Cao Y, Wang Y, Zhou Z, Peng X, Wang J, Xie X, Wei W*. (2022) Circular RNA Vaccines against SARS-CoV-2 and Emerging Variants. Cell 185, 1728-1744 e1716.
  2. Yi Z, Qu L, Tang H, Liu Z, Liu Y, Tian F, Wang C, Zhang X, Feng Z, Yu Y, Yuan P, Yi Z, Zhao Y, Wei W*. (2022) Engineered circular ADAR-recruiting RNAs increase the efficiency and fidelity of RNA editing in vitro and in vivo. Nature Biotechnology 40(6): 946-955.
  3. Xu P, Liu Z, Liu Y, Ma H, Xu Y, Bao Y, Zhu S, Cao Z, Wu Z, Zhou Z and Wei W*. (2021) Genome-wide interrogation of gene functions through base editor screens empowered by barcoded sgRNAs. Nature Biotechnology. 39, 1403–1413.
  4. Qu L, Yi Z, Zhu S, Wang C, Cao Z, Zhou Z, Yuan P, Tian F, Liu Z, Bao Y, Zhao Y, Wei W*. (2019) Programmable RNA editing by recruiting endogenous ADAR using engineered RNAs. Nature Biotechnology. 37, 1059-1069.
  5. Zhao X, Zhang G, Liu S, Chen X, Peng R, Dai L, Qu X, Li S, Song H, Gao Z, Yuan P, Liu Z, Li C, Shang Z, Li Y, Zhang M, Qi J, Wang H, Du N, Wu Y, Bi YH, Gao S, Shi Y, Yan J, Zhang Y, Xie Z*, Wei WS* and Gao GF*. (2019) Human neonatal Fc receptor is the cellular uncoating receptor for enterovirus B. Cell. 177, 1-13.
  6. Liu Y, Cao Z, Wang Y, Guo Y, Xu P, Yuan P, Liu Z, He Y and Wei W*. (2018) Genome-wide screening for functional long noncoding RNAs in human cells by Cas9 targeting of splice sites. Nature Biotechnology. 36, 1203-1210.
  7. Zhu S, Li W, Liu J, Chen C-H, Liao Q, Xu P, Xu H, Xiao T, Cao Z, Peng J, Yuan P, Brown M, Liu X* & Wei W*. (2016) Genome-scale deletion screening of human long non-coding RNAs using a paired-guide RNA CRISPR library. Nature Biotechnology. 34, 1279-1286.
  8. Zhou Y, Zhu S, Cai C, Yuan P, Li C, Huang Y and Wei W*. (2014) High-throughput Screening of a CRISPR/Cas Library for Functional Genomics in Human Cells. Nature 509(7501): 487-91.
  9. Yang J, Zhang Y, Yuan P, Cai C, Ren Q, Guo S, Zhu C, Qi H and Wei W*. (2014) Complete Decoding of DNA Recognition by TAL Effector RVDs. Cell Res. 24:628-631.