Add:Rm.306, Biomedical Pioneering Innovation Center, Integrated Science Research Center No.2,Peking University
Mailing Address:BIOPIC, Integrated Science Research Center No.2, Peking University, Yiheyuan Rd., No. 5, Haidian District, Beijing, 100871

Lab Web:

Zemin Zhang

2022.03-Present, Director, Biomedical Pioneering Innovation Center, Peking University

2014-PresentTenured Full Professor, Peking University, School of Life Sciences

2014-PresentPeking University-Tsinghua University Center of Life Sciences, Senior Principle Investigator

2014-PresentBIOPICPeking University, Principal Investigator

1998-2014, Genentech Inc., South San Francisco, CA

1995-1998, Postdoctoral Fellow, Howard Hughes Medical Institute (Laboratory of Yuet Wai Kan) University of California, San Francisco, CA

Research Interests

Zhang Lab is devoted to using the cutting-edge genomics and bioinformatics technologies to study critical issues of cancer biology, including revealing the genetic and immune factors underlying tumorigenesis, tumor microenvironment and drug resistance. The current main research directions include: 1) applying single cell sequencing technology to dissect tumor microenvironment, especially the accurate composition and functional status of tumor-infiltrating immune cells; 2) dissecting the heterogeneity of tumor and the impact on cancer biology and drug resistance; 3) developing innovative bioinformatics tools and resources to analyze, integrate, and visualize single-cell genomic data and large-scale cancer genomic data to reveal novel targets as well as the genomic mechanisms underlying tumor heterogeneity and immune response differences.

Awards and Honors

2023, Member of Chinese Academy of Science

2020, Cell Press Paper of the Year Award (2019) in China

2019 Top 10 Advances of Bioinformatics in China (selected in 2020)

2019, Bayer Investigator Award

2018, Cell Press Paper of the Year Award (2017) in China

2018 Top 10 Advances of Bioinformatics in China (selected in 2019)

2018, Scientific Chinese Person of the Year (Biology)

2017 Top 10 Advances of Biological Sciences in China (selected in 2018)

2017 Top 10 Biomedical Advances in China (selected in 2018)

2017, The Boehringer Ingelheim Investigator Award

2017, Peking University Translational Research Individual PI Award

2014, Cheung Kong Scholar, awarded by the Ministry of Education and Li Ka Shing Foundation

1989 CUSBEA Scholar (China-US Biochemistry Exchange and Application Program)

Featured scientist in the 2005 Genentech Annual Report, and 2012 Genentech Billboard (with theme “To us, science is personal”)

Genentech Key Contributor Awards (multiple times)

Selected Publication

1. B. Liu, X. Hu, K. Feng, R. Gao, Z. Xue, S. Zhang, Y. Zhang, E. Corse, Y. Hu, W. Han*, and Z. Zhang*. (2022) Temporal single-cell tracing reveals clonal revival and expansion of precursor exhausted T cells during anti-PD-1 therapy in lung cancer. Nat Cancer, 3:108–121

2. L. Zheng, S. Qin, W. Si, A. Wang, B. Xing, R. Gao, X. Ren, L. Wang, X. Wu, J. Zhang, N. Wu, N. Zhang, H. Zhang, H. Ouyang, K. Chen, Z. Bu*, X. Hu*, J. Ji*and Z. Zhang*. (2021) Pan-cancer single-cell landscape of tumor-infiltrating T cells. Science, 374, eabe6474, DOI: 10.1126/science.abe6474

3. S. Cheng, Z. Li, R. Gao, B. Xing, Y. Gao, Y. Yang, S. Qin, L. Zhang, H. Ouyang, P. Du, L. Jiang, B. Zhang, Y. Yang, X. Wang, X. Ren, J. Bei, X. Hu, Z. Bu*, J. Ji*, and Z. Zhang*. (2021) A pan-cancer single-cell transcriptional atlas of tumor infiltrating myeloid cells. Cell, 184(3): 792-809

4.  X. Ren, W. Wen, X. Fan, W. Hou, B. Su, P.i Cai, J. Li, Y. Liu, F. Tang, F. Zhang, Y. Yang, J. He, W. Ma, J. He, P. Wang, … P. Zhou*, Q. Jiang*, Z. Huang*, J-X Bei*, L. Wei*, X-W Bian*, X. Liu*, T Cheng*, X. Li*, P. Zhao*, F-S Wang*, H. Wang*, B. Su*, Z. Zhang*, K. Qu*, X. Wang*, J. Chen*, R. Jin*, and Z. Zhang*, (2021) COVID-19 immune features revealed by a large-scale single cell transcriptome atlas, Cell, 184:1895-1913

5. L. Zhang, Z. Li, K. M. Skrzypczynska, Q. Fang, W. Zhang, S. A. O’Brien, Y. He, L. Wang, Q. Zhang, A. Kim, R. Gao, J. Orf, T. Wang, D. Sawant, J. Kang, D. Bhatt, D. Lu, C-M Li, A. Rapaport, K. Perez, Y. Ye, S. Wang, X. Hu, X. Ren, W. Ouyang, Z. Shen*, J.G. Egen*, Z Zhang*, and X. Yu*. (2020) Single-cell analyses inform mechanisms of myeloid-targeted therapies in colon cancer.Cell, 181:442-459

6. Q. Zhang, Y. He, N. Luo, S. J. Patel, Y. Han, R. Gao, M. Modak, S. Carotta, C. Haslinger, D. Kind, G. W. Peet, G. Zhong, S. Lu, W. Zhu, Y. Mao, M. Xiao, M. Bergmann, X. Hu, S. P. Kerkar, A. B. Vogt, S. Pflanz, K. Liu*, J. Peng*, X. Ren*, and Z. Zhang* (2019) Landscape and dynamics of single immune cells in hepatocellular carcinoma. Cell, 179:829-845

7. L. Zhang, X. Yu, L. Zheng, Y. Zhang, Y. Li, Q. Fang, R. Gao, B. Kang, Q. Zhang, J.Y. Huang, H. Konno, X. Guo, Y. Ye, S. Gao, S. Wang, X. Hu, X. Ren, Z. Shen*, W. Ouyang*, and Z. Zhang*. (2019) Lineage tracking reveals dynamic relationships of T cells in colorectal cancer. Nature, 564:268-272