2025-present, Peking University, BIOPIC, Professor

2020-2022, Peking University, Beijing Advanced Innovation Center for Genomics, PI

2014-present, Peking University, School of Life Sciences, Assistant Professor-Associate Professor-Professor

2014-present, Peking University, Center for Life Science, PI

2009-2013, UC San Diego, Pharmacology, Postdoc Scholar, Assistant Project Scientist (Mentor: Jack Dixon)

2003-2008, University of Michigan, Biological Chemistry，Ph.D. (Mentor: Zhaohui Xu)

2002-2003, Peking University, School of Life Sciences, Research Assistant

1998-2002, Peking University, Biochemistry and Molecular Biology, B.S.

Since joining PKU in 2014, my research initially focused on a group of novel kinases that phosphorylate secreted proteins and glycans, building on the work I conducted during my postdoctoral training in Dr. Jack Dixon’s laboratory. In recent years, we have made a shift in our primary focus, directing our main efforts toward exploring the molecular mechanisms underlying immunoglobulins, particularly IgM, IgA, and IgE. Additionally, I have been involved in studying the antibody response to SARS-CoV-2. In future work, we plan to delve deeper into the molecular mechanisms of various immunoglobulins, including examining the interactions between different immunoglobulins and their specific receptors and binding partners, as well as exploring the interplay between immunoglobulins and pathogen molecules. We also intend to extend our research to investigate the molecular mechanisms of complement proteins. Finally, we aim to leverage our insights into antibody engineering, with the ultimate goal of guiding the development of new therapies to improve human health.

2023     C.C.Tan Life Science Innovation Award

2023     National Science Fund for Distinguished Young Scholars

2021     Wuxi AppTec Life Science and Chemistry Award for Outstanding Achievement

2021     Gu Xiaocheng Lecture award

2020     VCANBIO Award for Innovations and Breakthrough in Life Sciences and Medicine

​(*indicates corresponding or co-corresponding authors)

1.    Deng, M., Du, S.*, Hou, H., Xiao, J.* (2024). Structural insights into the high-affinity IgE receptor FcεRI complex. Nature 633:952-959.

2.    Wang, Y., Su, C., Ji, C., Xiao, J.* (2024). CD5L associates with IgM via the J chain. Nature Communications 15:8397.

3.    Yang X, Zhu M, Lu X, Wang Y, Xiao J. * (2024). Architecture and activation of human muscle phosphorylase kinase. Nature Communications 15:2719.

4.    Li, Y., Shen, H., Zhang, R., Ji, C., Wang, Y., Su, C., Xiao, J.* (2023). Immunoglobulin M Perception by FcμR. Nature 615:907-912.

5.    Ji, C., Shen, H., Su, C., Li, Y., Chen, S., Sharp, T.H., Xiao, J.* (2023). Plasmodium falciparum has evolved multiple mechanisms to hijack human immunoglobulin M. Nature Communications 14:2650.

6.    Cao, Y.*, Yisimayi, A., Jian, F., Song, W., Xiao, T., Wang, L., Du, S., Wang, J., Li, Q., Chen, X., Yu, Y., Wang, P., Zhang, Z., Liu, P., An, R., Hao, X., Wang, Y., Wang, J., Feng, R., Sun, H., Zhao, L., Zhang, W., Zhao, D., Zheng, J., Yu, L., Li, C., Zhang, N., Wang, R., Niu, X., Yang, S., Song, X., Chai, Y., Hu, Y., Shi, Y., Zheng, L., Li, Z., Gu, Q., Shao, F., Huang, W., Jin, R., Shen, Z.*, Wang, Y.*, Wang, X.*, Xiao, J.*, Xie, X.S.* (2022). BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection. Nature 608:593-602.

7.    Du, S., Cao, Y., Zhu, Q., Yu, P., Qi. F., Wang, G., Du, X., Bao, L., Deng, W., Zhu, H., Liu, J., Nie, J., Zheng, Y., Liang, H., Liu, R., Gong, S., Xu, H., Yisimayi, A., Lv, Q., Wang, B., He, R., Han, Y., Zhao, W., Bai, Y., Qu, Y., Gao, X., Ji, C., Wang, Q., Gao, N., Huang, W., Wang, Y., Xie, S.X.*, Su, X.-d.*, Xiao, J.*, Qin, C.* (2020). Structurally resolved SARS-CoV-2 antibody shows high efficacy in severely infected hamsters and provides a potent cocktail pairing strategy. Cell 183:1013-1023.e13.

8.    Wang, Y., Wang, G., Li, Y., Zhu, Q., Shen, H., Gao, N., Xiao, J.* (2020). Structural insights into secretory immunoglobulin A and its interaction with a pneumococcal adhesin. Cell Research 30:602-609.

9.    Li, Y., Wang, G., Li, N., Wang, Y., Zhu, Q., Chu, H., Wu, W., Tan, Y., Yu, F., Su, X.D., Gao, N., Xiao, J.* (2020). Structural insights into immunoglobulin M. Science 367:1014-1017.

10. Zhang, H., Zhu, Q., Cui, J., Wang, Y., Chen, M.J., Guo, X., Tagliabracci, V.S., Dixon, J.E., Xiao, J.* (2018). Structure and evolution of the Fam20 kinases. Nature Communications 9:1218.