报告题目：DNA probes for highly multiplexed, precisely quantitative, 

          ultra-resolution imaging

报告人：Prof. Peng Yin

        Harvard University

时间：2014年12月5日（周五）上午9：00

地点：北京大学综合科研楼302会议室

联系人：黄岩谊（62744058）

摘要：Living organisms are complex molecular systems. Imaging provides a natural and direct way to investigate such systems and is thus becoming a central tool for biomedical science. However, due to limitations of current microscopy, scientists face three crippling changes when attempting to visualize biology on the molecular scale: blurred vision (i.e. inability to visualize individual molecules clearly, especially for crowded targets), (partial) color blindness (i.e. only a small number [typically 3 or 4] of colors are used to simultaneously track distinct molecular species), and ambiguous quantification (i.e. inability to precisely count the number of target molecules in a resolution limited area). Using programmable fluorescent DNA probes (Nature Methods, 11:313, 2014; Science 344:65, 2014), we present a highly multiplexed (10× demonstrated), precisely quantitative (>90% precision), and ultra-high resolution (sub-5 nm) optical imaging method that simultaneously addresses these challenges, and hence promises to broadly transform biomedical research.