首页» 中心PI» 苏晓东
联系方式

E-mail:xdsu@pku.edu.cn
办公电话:+86-010-62759743
办公地点:北京大学生命科学学院大楼S407室
邮件地址:北京市海淀区颐和园路5号北京大学生物医学前沿创新中心305室,100871

研究组主页:

苏晓东
BIOPIC常务副主任、研究员
个人履历

2010-至今, 北京大学生物医学前沿创新中心常务副主任

2005-至今,《生物物理与生物化学进展》编委

2004-至今,中国晶体学会秘书长

2003-至今,北京大学生命科学学院长江特聘教授,北大“蛋白质工程及植物基因工程国家重点实验室副主任

1998-2002 历任瑞典隆德(Lund)大学化学中心助教和副教授

1995-1998 美国加州理工学院生物学部Howard Hughes Medical Institute(HHMI)博士后

1994,理学博士,瑞典皇家Karolinska医学院,

1985,理学学士,北京大学

主要研究方向

X-ray Crystallography; Protein Structure and Protein Chemistry; Single Molecule Biophysics; Enzymology; Molecular biology; Drug design; Protein Engineering.

获奖及荣誉

2016拜耳学者

2003 国家基金委(NSFS)国家杰出青年科学基金

2002 教育部长江学者奖励

代表性论文及论著
  1. Li, Hongling; Zhu, Li; Chen, Huimin; Li, Tangping; Han, Qin; Wang, Shihua; Yao, Xinglei; Feng, Hongli; Fan, Linyuan; Gao, Shaorong; Boyd, Richard; Cao, Xu; Zhu, Ping; Li, Jing; Keating, Armand; Su, Xiaodong; Zhao, Robert Chunhua. Generation of Functional Hepatocytes from Human Adipose-Derived MYC+ KLF4+ GMNN+ Stem Cells Analyzed by Single-Cell RNA-Seq Profiling. Stem cells translational medicine.  2018  7(11) 792-805.
  2. Deng, Ming-Jing; Tao, Jianli; E, Chao; Ye, Zhao-Yang; Jiang, Zhengfan; Yu, Jin; Su, Xiao-Dong. Novel Mechanism for Cyclic Dinucleotide Degradation Revealed by Structural Studies of Vibrio Phosphodiesterase V-cGAP3.  Journal of molecular biology.  2018.
  3. Wang C, Guan Y, Lv M, Zhang R, Guo Z, Wei X, Du X, Yang J, Li T, Wan Y, Su X, Huang X, Jiang Z. Manganese Increases the Sensitivity of the cGAS-STING Pathway for Double-Stranded DNA and Is Required for the Host Defense against DNA Viruses. Immunity. 2018 Apr 5. pii: S1074-7613(18)30093-1.
  4. Lian TF, Xu YP, Li LF and Su XD. Crystal Structure of Tetrameric Arabidopsis MYC2 Reveals the Mechanism of Enhanced Interaction with DNA. Cell Rep. 2017;19:1334-1342.
  5. Wang Y, Ning X, Gao P, Wu S, Sha M, Lv M, Zhou X, Gao J, Fang R, Meng G, Su X and Jiang Z. Inflammasome Activation Triggers Caspase-1-Mediated Cleavage of cGAS to Regulate Responses to DNA Virus Infection. Immunity. 2017;46:393-404.
  6. Liu M, Liu Y, Di J, Su Z, Yang H, Jiang B, Wang Z, Zhuang M, Bai F and Su X. Multi-region and single-cell sequencing reveal variable genomic heterogeneity in rectal cancer. BMC Cancer. 2017;17:787.
  7. Tao J, Zhang XW, Jin J, Du XX, Lian T, Yang J, Zhou X, Jiang Z and Su XD. Nonspecific DNA Binding of cGAS N Terminus Promotes cGAS Activation. J Immunol. 2017;198:3627-3636.
  8. Li X, Nai S, Ding Y, Geng Q, Zhu B, Yu K, Zhu W-G, Dong M-Q, Su X-D, Xu X and Li J. Polo-like kinase 1 (PLK1)-dependent phosphorylation of methylenetetrahydrofolate reductase (MTHFR) regulates replication via histone methylation. Cell Cycle. 2017;16:1933-1942.
  9. Che X, Du XX, Cai X, Zhang J, Xie WJ, Long Z, Ye ZY, Zhang H, Yang L, Su XD and Gao YQ. Single Mutations Reshape the Structural Correlation Network of the DMXAA-Human STING Complex. J Phys Chem B. 2017;121:2073-2082.
  10. Da L-T, E C, Shuai Y, Wu S, Su X-D and Yu J. T7 RNA polymerase translocation is facilitated by a helix opening on the fingers domain that may also prevent backtracking. Nucleic Acids Research. 2017;45:7909-7921.
  11. Sangjin Kim, Erik Brostrouml;mer, Dong Xing, Jianshi Jin, Shasha Chong, Hao Ge, Siyuan Wang, Gu C, Yang L, Gao YQ, Xiao-dong Su*, Yujie Sun* & X. Sunney Xie* ;Probing Allostery Through DNA; (2013) Science. 2013 Feb 15;339(6121):816-9.
  12. Wang Z, Wu Y, Li L, Su XD “Intermolecular recognition revealed by the complex structure of human CLOCK-BMAL1 basic helix-loop-helix domains with E-box DNA.(2013) Cell Research. 2013 Feb; 23(2):213-24. doi: 10.1038/cr.2012.170. Epub 2012 Dec 11.
  13. Yi-He Huang, Xiang-Yu Liu, Xiao-Xia Du, Zheng-Fan Jiang & Xiao-Dong Su* ;The Structural Basis for the Sensing and Binding of Cyclic di-GMP by STING; (2012) Nature Structural & Molecular Biology, 2012 Jun 24;19(7):728-30. doi: 10.1038/nsmb.2333
  14. Cao Q, Wang XJ, Liu CW, Liu DF, Li LF, Gao YQ, Su XD.Inhibitory mechanism of caspase-6 phosphorylation revealed by crystal structures, molecular dynamics (MD) simulations and biochemical assays.J Biol Chem. 2012 Mar 20.
  15. Wang KT, Desmolaize B, Nan J, Zhang XW, Li LF, Douthwaite S, Su XD.Structure of the bifunctional methyltransferase YcbY (RlmKL) that adds the m7G2069 and m2G2445 modifications in Escherichia coli 23S rRNA. Nucleic Acids Res. 2012 Feb 22.
  16. Xiao-Jun Wang, Xiang Liu, Kai-tuo Wang, Wei Mi, Yan Zhang, Lanfen LI, Andrea C, LeBlance, Xiao-Dong Su; Crystal structures of human caspase-6 reveal a novel intramolecular cleavage self-activation mechanism; (2010) EMBO Reports 11(11):841-7. Epub 2010 Oct 1.
  17. Nan B, Liu X, Zhou Y, Liu J, Zhang L, Wen J, Zhang X, Su XD, Wang YP; From Signal Perception to Signal Transduction: Ligand-Induced Dimeric Switch of DctB Sensory Domain in Solution; Molecular Microbiology (2010) 2010 Feb 10.
  18. Nan J, Brostromer E, Liu XY, Kristensen O, Su XD; Bioinformatics and structural characterization of a hypothetical protein from Streptococcus mutans: implication of antibiotic resistance. PLoS One. (2009) Oct 2;4(10):e7245.
  19. Jian Lei, Lan-Fen Li, Xiao-Dong Su “Crystal structures of phosphotransferase system enzymes PtxB (IIB(Asc)) and PtxA (IIA(Asc)) from Streptococcus mutans. (2009) J Mol Biol. 2009 Feb 20; 386(2):465-75. Epub 2008 Dec 25.
  20. Cong Liu, Dan Li, Lan-Fen Li, Xiao-Dong Su;Ring-Opening Mechanism Revealed by Crystal Structures of NagB and Its ES Intermediate Complex; (2008) J Mol Biol. 379 (1):73-81
  21. Yanfeng Zhou, Beiyan Nan, Jie Nan, Qingjun Ma, Santosh Panjikar, Yuhe Liang, Yiping Wang and Xiao-Dong Su;C4-dicarboxylates sensing mechanism revealed by the crystal structures of DctB sensor domain; (2008) J Mol Biol. 383 (1):49-61. Epub 2008 Aug 12
  22. Ming-Rui Duan, Jie Nan, Yu-He Liang, Peng Mao, Lu Lu, Luhua Lai, *Yi Li, and *Xiao-Dong Su; DNA Binding Mechanism Revealed by High Resolution Crystal Structure of Arabidopsis thaliana WRKY1 Protein; Nucleic acid research (2007) 35(4):1145-54
  23. Su XD, Liang Y, Li L, Nan J, Brostromer E, Liu P, Dong Y, Xian D.; A large-scale, high-efficiency and low-cost platform for structural genomics studies; Acta Crystallogr D Biol Crystallogr. (2006) 62(8):843-51
  24. Yu Y, Liang YH, Brostromer E, Quan JM, Panjikar S, Dong YH, Su XD; A catalytic mechanism revealed by the crystal structures of the imidazolonepropionase from Bacillus subtilis;. J Biol Chem. (2006) 281(48):36929-36
  25. Marcia Alvarez-Fernandez, Yuhe Liang, Magnus Abrahamson and Xiao-Dong Su. “Crystal structure of human cystatin D, a cysteine peptidase inhibitor with restricted inhibition profile, (2005) J. Biol. Chem. 280:18221-18228.
  26. Hui Ren, Liya Wang, Matthew Bennett, Yuhe Liang, Xiaofeng Zheng, Fei Lu, Lanfen Li, Jie Nan, Ming Luo, Staffan Eriksson, Chuanmao Zhang, and Xiao-Dong Su;The Crystal Structure of human Adenylate Kinase 6: An Adenylate Kinase Localized to the Cell Nucleus; (2005) Proc. Natl. Acad. Sci. USA (PNAS) 102:303-308
  27. Selmer, M; and Su, X-D; Crystal structure of an mRNA binding fragment of Moorella thermoacetica SelB; (2002) EMBO J. 21 (15) 4145-53
  28. Bennett M; Guan, Z; Laurberg M and SU, X-D; Bacillus subtillis arsenate reductase is structurally and functionally similar to low- molecular-weight protein tyrosine phosphatases; (2001) Proc. Natl. Acad. Sci, USA (PNAS) 98 13577-13582.
  29. Su, X-D; Gastinel, LN; Vaugh, DE; Faye, I; Poon,P & Bjorkman, PJ. Crystall structure of hemolin: A horseshoe shape with implications for hemophilic adhesion; (1998) Science 281 991-995.
  30. Su, X-D; Taddei, N; Stefani, M; Ranponi, G & Nordlund, P; The crystal structure of a lowmolecular-weight phosphotyrosine protein phosphatase; (1994) Nature 370 575-578