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联系方式

办公电话:+86-010-62751674
办公地点:北京大学综合科研楼生物医学前沿创新中心311室
邮件地址:北京市海淀区颐和园路5号北京大学综合科研楼,100871

研究组主页:http://bicmr.pku.edu.cn/~gehao/

葛颢
BIOPIC 研究员
个人履历

2011-现在,北京大学生物医学前沿创新中心,研究员

2011-现在,北京国际数学研究中心,副教授

2010-2011,哈佛大学化学与生物化学系,访问学者

2010-2011,复旦大学数学科学学院,副教授

2008-2009,复旦大学数学科学学院,讲师

2008,北京大学,理学博士

2004,北京大学,理学学士

主要研究方向

非平衡态热力学和统计物理;单分子物理化学;生物数学;生物物理化学。 概率论与随机过程作为数学的一个重要分支,是伴随着十九世纪中叶到二十世纪初的统计力学发展并壮大起来的。而与此同时,该理论也已经广泛应用于物理化学的各个角落,并随着近些年来实验技术的突飞猛进而有越来越流行的趋势。我们希望通过深入研究现代科学中的随机数学模型,尝试研究和回答其他学科的基本问题,试图给出一些更深刻的更定量的结果。 该研究方向综合多学科的知识,涉及到数学、物理、化学以及生物,甚至涉及工程学上使用的信息论等等。

获奖及荣誉

2017, 北京大学黄廷芳/信和青年杰出学者奖

2016,  NSFC优秀青年基金

2016,  教育部长江学者奖励计划青年学者

2010,全国优秀博士论文

2009,中国数学会"家庆数学奖"(优秀博士论文奖)

代表性论文及论著
  1. Bai, SN; Ge, H; Qian, H. Structure for energy cycle: a unique status of the second law of thermodynamics for living systems. SCIENCE CHINA-LIFE SCIENCES.  2018 61(10)1266-1273.
  2. You, ZY; Li, LY; Lu, JF; Ge, H. Integrated tempering enhanced sampling method as the infinite switching limit of simulated tempering.  JOURNAL OF CHEMICAL PHYSICS.  2018 149(8) 084114.
  3. Yang, Shi-Xian; Ge, Hao.  Physical review. E. Decomposition of the entropy production rate and nonequilibrium thermodynamics of switching diffusion processes. 2018 98(1-1) 012418.
  4. Jin, X; Ge, H. Nonequilibrium steady state of biochemical cycle kinetics under non-isothermal conditions.  NEW JOURNAL OF PHYSICS.  2018 20(043030).
  5. Ge, H., Jia, C. & Jiang, D.-Q. Cycle symmetry, limit theorems, and fluctuation theorems for diffusion processes on the circle. Stochastic Processes and their Applications 127, 1897-1925 (2017).
  6. Xu, B., Ge, H. & Zhang, Z. An efficient and assumption-free method to approximate protein level distribution in the two-states gene expression model. Journal of Theoretical Biology 433, 1-7 (2017).
  7. Ge, H. & Qian, H. Mathematical Formalism of Nonequilibrium Thermodynamics for Nonlinear Chemical Reaction Systems with General Rate Law. Journal of Statistical Physics 166, 190-209 (2017).
  8. Ai, G., Liu, P. & Ge, H. Torque-coupled thermodynamic model for F_{o}F_{1}-ATPase. Physical review. E 95, 052413 (2017).
  9. Ge, H. and Qian, H.: Mesoscopic kinetic basis of macroscopic chemical thermodynamics: A mathematical theory. Phys. Rev. E 94, 052150 (2016)
  10. Zhao, Z.Q., Xie, X.S. and Ge, H.: Nonequilibrium Relaxation of Conformational Dynamics Facilitates Catalytic Reaction in an Elastic Network Model of T7 DNA Polymerase. J. Phys. Chem. B 120, 2869-877 (2016)
  11. Ge, H., Qian, H. and Xie, X.S.: Stochastic phenotype transition of a single cell in an intermediate region of gene state switching. Phys. Rev. Lett. 114, 078101 (2015)
  12. Ge, H.: Mathematical laws of randomness. In Voices: Expanding the Biology Toolkit. Cell 163, 1306 (2015)
  13. Ge, H.: Time reversibility and nonequilibrium thermodynamics of second-order stochastic processes. Phys. Rev. E 89, 022127 (2014)
  14. Ge, H.: Stochastic Theory of Nonequilibrium Statistical Physics (review). Advances in Mathematics(China) 43, 161-174 (2014)
  15. Chong, S.S., Chen, C.Y., Ge, H. and Xie, X.S.: Mechanism of transcriptional bursting in bacteria. Cell 158, 314–326 (2014)
  16. Kim, S., Brostr?mer, E., Xing, D., Jin, J.S., Chong, S.S., Ge, H., Wang, S.Y., Gu, C., Yang, L., Gao, Y.Q., Su, X.D., Sun, Y.J. & Xie, X.S.: Probing allostery through DNA. Science 339 816 (2013)
  17. Xu, X.L., Ge, H., Gu, C., Gao, Y. Q., Wang, S.Y., Thio, B., Hynes, J., Xie, X.S. and Cao, J.S.: Modeling spatial correlation of DNA deformation: DNA allostery in protein binding. J. Phys. Chem. B 117, 13378-13387 (2013) (co-first-author)
  18. Ge, H., Qian, M. and Qian,H.: Stochastic theory of nonequilibrium steady states. Part II: Applications in chemical biophysics.Phys. Rep. 510, 87-118 (2012)
  19. Ge, H., Pressé, S., Ghosh, K. and Dill, K.: Markov processes follow from the principle of maximum caliber. J. Chem. Phys. 136, 064108 (2012) (Research highlighted)
  20. Ge, H.: Multivariable fluctuation theorems in the steady-state cycle kinetics of single enzyme with competing substrates.J. Phys. A: Math. Theor. 45 215002 (2012) (Research highlighted)
  21. Ge, H. and Qian, H.: The physical origins of entropy production, free energy dissipation and their mathematical representations. Phys. Rev. E 81 051133 (2010)
  22. Ge, H.: Extended forms of the second law for general time-dependent stochastic processes. Phys. Rev. E 80 021137 (2009)
  23. Ge, H. and Qian, H.: Thermodynamic limit of a nonequilibrium steady state: Maxwell-type construction for a bistable biochemical system. Phys. Rev. Lett. 103, 148103 (2009)
  24. Ge, H.: Waiting cycle times and generalized Haldane equality in the steady-state cycle kinetics of single enzymes. J. Phys. Chem. B 112 61-70 (2008)
  25. Ge, H. and Jiang, D.Q.: Generalized Jarzynski’s equality of multidimensional inhomogeneous diffusion processes. J. Stat. Phys. 131 675-689 (2008)