首页» 中心PI» 孙育杰
联系方式

E-mail:sun_yujie@pku.edu.cn
办公电话:+86-010-62744060(4054)
办公地点:北京大学综合科研楼生物医学前沿创新中心334室

研究组主页:https://b.eqxiu.com/s/PmknAwHw?eqrcode=1&share_level=1&from_user=20200514671db281&from_id=2a359569-6&share_time=1592740748956

孙育杰
BIOPIC 研究员
个人履历

2014-现在, 北京大学生物医学前沿创新中心(BIOPIC)研究员,及化学与分子工程学院兼职副教授

2010-2014, 北京大学生物医学前沿创新中心(BIOPIC)副研究员,及化学与分子工程学院兼职副教授

2005-2010美国宾大肌肉研究所及纳米/生物交叉研究中心,博士后及Senior Research Investigator

2005University of Pittsburgh,理学博士

1999,中国科学技术大学,理学硕士

1996,中国科学技术大学,理学学士

主要研究方向

单分子技术已成为研究生命科学的重要手段,其终极目标之一就是在体内实时观测单分子包括生物大分子的运动,并以此在分子水平上理解生理条件下的细胞过程。我们单分子及活细胞超高分辨率成像实验室的主要方向就是开创、发展和应用新的和现有的单分子技术,包括发展超高分辨率单分子荧光成像技术和单分子操作及力学测量技术,以在单分子水平上研究活细胞,如癌细胞和干细胞的基因表达和调控,进而推动癌症治疗和干细胞研究应用。运用超分辨成像和活细胞成像,我们将与其他BIOPICPI合作推进以下几个方向的研究:(1)真核细胞如何利用和控制其基因转录和翻译过程中的内在以及外部噪音;(2)解析染色质的结构,分布及其在基因转录中构型改变的动力学过程。(3)最终理解细胞基因表达中脉冲过程产生和调控的机理,并用于癌症细胞以及干细胞分化机理的研究。

获奖及荣誉

2017,拜尔学者奖

2014,通化东宝生命科学奖教金

2012,SCOPUS 青年科学家生命科学银奖

代表性论文及论著

1. Hongchen Zhang, Shipeng Shao*, Yong Zeng, Xiaotian Wang, Yizhi Qin, Qiunan Ren, Shengqi Xiang, Yuxin Wang, Junyu Xiao, and Yujie Sun*, “Reversible Phase Separation of HSF1 Is Required for Acute Transcriptional Response During Heat Shock.” Nat Cell Biol, 2022, 24: 340–352.

2. J Yuyang Lu, Lei Chang, Tong Li, Ting Wang , Yafei Yin, Ge Zhan, Xue Han, Ke Zhang, Yibing Tao, Michelle Percharde, Liang Wang, Qi Peng, Pixi Yan, Hui Zhang, Xianju Bi, Wen Shao, Yantao Hong, Zhongyang Wu, Runze Ma, Peizhe Wang, Wenzhi Li, Jing Zhang, Zai Chang, Yingping Hou, Bing Zhu, Miguel Ramalho-Santos, Pilong Li, Wei Xie, Jie Na, Yujie Sun* and Xiaohua Shen*, “Homotypic Clustering of L1 and B1/Alu Repeats Compartmentalizes the 3D Genome”, Cell Res, 2021, 31(6): 613-630.

3. Qian Peter Su*, Ziqing Winston Zhao*, Luming Meng, Miao Ding, Weiwei Zhang, Yongzheng Li, Mengzhu Liu, Rongqin Li,Yi-Qin Gao, Xiaoliang Sunney Xie*, and Yujie Sun*, “Super-resolution Imaging Reveals Spatio-temporal Propagation of Human Replication Foci Mediated by CTCF-organized Chromatin Structures”, Proc. Natl. Acad. Sci. USA, 2020, 117(26), 15036-15046.

4. Mian Wei, Xiaoying Fan, Miao Ding, Ruifeng Li, Shipeng Shao, Yingping Hou, Shaoshuai Meng, Fuchou Tang, Cheng Li, Yujie Sun*, “Nuclear actin regulates inducible transcription by enhancing RNA polymerase II clustering”, Sci Adv, 2020, 6: eaay6515.

5. Hao, H., Niu, J., Xue, B., Su, Q. P., Liu, M., Yang, J., Qin, J., Zhao, S., Wu, C.*, Sun, Y.*, "Golgi-associated Microtubules Are Fast Cargo Tracks and Required for Persistent Cell Migration." EMBO Rep, 2020, 21: e48385.

6. Xuanze Chen, Rongqin Li, Zhihe Liu, Kai Sun, Zezhou Sun, Danni Chen, Gaixia Xu, Peng Xi, Changfeng Wu*, & Yujie Sun*, “Photoblinking Small Semiconductor Polymer Dots for Fluorescence Nanoscopy”, Adv Mater, 2017, 29(5): 1604850.

7. Xuanze Chen, Mian Wei, M. Mocarlo Zheng, Jiaxi Zhao, Huiwen Hao, Lei Chang, Peng Xi, and Yujie Sun*, “Study of RNA Polymerase II Clustering inside Live-Cell Nuclei Using Bayesian Nanoscopy”, ACS Nano, 2016, 10: 2447–54.

8. Shipeng Shao, Weiwei Zhang, Huan Hu, Boxin Xue, Jinshan Qin, Chaoying Sun, Yuao Sun, Wensheng Wei, Yujie Sun*, “Long-term Dual-color Tracking of Genomic Loci by Modified sgRNAs of the CRISPR/Cas9 System”, Nucleic Acids Res., 2016, 44: e86.

9. Zhen Liu, Dong Xing, Qian Su, Xinyu Kong, Jiamei Zhang, Boxin Xue, Hao Sun, Sheng Wang, Yile Tao, Yujie Sun*, “Superresolution Imaging and Tracking of Protein-Protein Interaction in Subdiffraction Cellular Space”, Nature Comm., 2014, 5: 4443-49.

10. Sangjin Kim, Erik Broströmer, Dong Xing, Jianshi Jin, Shasha Chong, Hao Ge, Siyuan Wang, Chan Gu, Lijiang Yang, Yi Qin Gao, Xiao-dong Su*, Yujie Sun*, X. Sunney Xie*, “Probing Allostery Through DNA”, Science, 2013, 339: 816-819.