首页» 中心PI» 魏文胜
联系方式

E-mail:wswei@pku.edu.cn
办公电话:+86-010-62757227
办公地点:北京大学生命科学学院202室
邮件地址:北京市海淀区颐和园路5号北京大学生命科学学院202室,100871

研究组主页:http://weilab.pku.edu.cn/

魏文胜
BIOPIC、ICG 研究员
个人履历

2019 - 现在, 教授 (tenure), 北京大学生命科学学院

2016 - 现在, 研究员, 北京未来基因诊断高精尖创新中心(ICG

2015 - 现在, 研究员, 北大-清华生命科学联合中心CLS

2014 - 现在, 研究员, 北京大学生物医学集成创新研究所(BIOPIC

2007 - 现在, 研究员, 北京大学生命科学学院

2005 - 2007, Research Associate, 美国斯坦福大学医学院遗传学系

1999–2004, 博士后, 美国斯坦福大学医学院遗传学系

1995 - 1999, 理学博士, 遗传学,Michigan State University

1987 - 1991, 理学学士, 生物化学,北京大学

主要研究方向

致力于发展基因编辑技术、RNA疫苗及治疗技术;关注高通量功能基因组学技术的发展及应用;在此基础上研究癌症、感染等重大疾病的分子机制,为发展高效治疗手段提供新的药物靶点、思路和方法。

获奖及荣誉

BI Investigatorship Award,2019

2018年度北京大学生命科学学院未名杰出科研奖,2019

第四届北京大学产学研项目合作先进个人奖,2019

北京市科学技术奖,2018

中国科技部创新人才推进计划科技创新创业人才,2018

北京大学教学优秀奖,2018

谈家桢生命科学创新奖,2016

中国专利优秀奖,2016

科学中国人年度人物,2016

北京大学郑昌学教学优秀奖,2015

Bayer Investigator Award2014

The Roche Chinese Young Investigator Award2014

北京大学东宝奖教金,2012

北京大学生命科学学院最受欢迎教师奖,2010

代表性论文及论著
  1. Liang Y, Zhang G, Li Q, Han L, Hu X, Guo Y, Tao W, Zhao X, Guo M, Gan T, Tong Y, Xu Y, Zhou Z, Ding Q, Wei W*, Zhong J*. (2021) TRIM26 is a critical host factor for HCV replication and contributes to host tropism. Science Advances 7, eabd9732.
  2. Zhang X, Yue D, Wang Y, Zhou Y, Liu Y, Qiu Y, Tian F, Yu Y, Zhou Z and Wei W*. (2019). PASTMUS: mapping functional elements at single amino acid resolution in human cells. Genome Biol. 20, 279.
  3. Qu L, Yi Z, Zhu S, Wang C, Cao Z, Zhou Z, Yuan P, Tian F, Liu Z, Bao Y, Zhao Y, Wei W*. (2019) Programmable RNA editing by recruiting endogenous ADAR using engineered RNAs. Nat. Biotechnol. 37, 1059-1069.
  4. Zhao X, Zhang G, Liu S, Chen X, Peng R, Dai L, Qu X, Li S, Song H, Gao Z, Yuan P, Liu Z, Li C, Shang Z, Li Y, Zhang M, Qi J, Wang H, Du N, Wu Y, Bi YH, Gao S, Shi Y, Yan J, Zhang Y, Xie Z*, Wei WS* and Gao GF*. (2019) Human neonatal Fc receptor is the cellular uncoating receptor for enterovirus B. Cell 177, 1-13.
  5. Zhu S, Cao Z, Liu Z, He Y, Wang Y, Yuan P, Li W, Tian F, Bao Y and Wei W*. (2019) Guide RNAs with embedded barcodes boost CRISPR-pooled screens. Genome Biol. 20, 20.
  6. Liu Y, Cao Z, Wang Y, Guo Y, Xu P, Yuan P, Liu Z, He Y and Wei W*. (2018) Genome-wide screening for functional long noncoding RNAs in human cells by Cas9 targeting of splice sites. Nat. Biotechnol.36, 1203-1210.
  7. Zhang H, Zhou Y, Wang Y, Zhao Y, Qiu Y, Zhang X, Yue D, Zhou Z, and Wei W*. (2018). A surrogate reporter system for multiplexable evaluation of CRISPR/Cas9 in targeted mutagenesis. Sci Rep 8, 1042.
  8. Zhang Y, Liu L, Guo S, Song J, Zhu C, Yue Z, Wei W* and Yi C*. (2017) Deciphering TAL effectors for 5-methylcytosine and 5-hydroxymethylcytosine recognition. Nat Commun 8(1): 901.
  9. He R, Peng J, Yuan P, Yang J, Wu X, Wang Y and Wei W*. (2017). Glucosyltransferase Activity of Clostridium difficile Toxin B Triggers Autophagy- mediated Cell Growth Arrest. Sci Rep 7(1): 10532.
  10. Zhou Y, Wang P, Tian F, Gao G, Huang L*, Wei W* and Xie X.S* (2017) Painting A Specific Chromosome with CRISPR/Cas9 for Live-cell Imaging.Cell Res. 27, 298-301.
  11. Zhou Y, Zhang H and Wei W*. (2016) Simultaneous generation of multi-gene knockouts in human cells. FEBS Letters 590, 4343-4353.
  12. Zhu S, Li W, Liu J, Chen C-H, Liao Q, Xu P, Xu H, Xiao T, Cao Z, Peng J, Yuan P, Brown M, Liu X* & Wei W*. (2016) Genome-scale deletion screening of human long non-coding RNAs using a paired-guide RNA CRISPR library. Nat Biotechnol 34, 1279-1286.
  13. He R, Peng J, Yuan P, Xu F, Wei W*. (2015) Divergent roles of BECN1 in LC3 lipidation and autophagosomal function. Autophagy 11:5, 740-747.
  14. Ren Q, Li C, Yuan P, Cai C, Luo G, Zhang L and Wei W*. (2015) A Dual-Reporter System for Real-Time Monitoring and High-throughput CRISPR/ Cas9 Library Screening of the Hepatitis C Virus. Sci. Rep. 5, 8865.
  15. Yuan P, Zhang H, Cai C, Zhu S, Zhou Y, Yang X, He R, Li C, Guo S, Li S, Huang T, Feng H and Wei W*. (2015) Chondroitin sulfate proteoglycan 4 functions as the cellular receptor for Clostridium difficile toxin B. Cell Res. 25:157-168.
  16. Zhou Y, Zhu S, Cai C, Yuan P, Li C, Huang Y and Wei W*. (2014) High-throughput Screening of a CRISPR/Cas Library for Functional Genomics in Human Cells. Nature 509(7501): 487-91.
  17. Yang J, Zhang Y, Yuan P, Cai C, Ren Q, Guo S, Zhu C, Qi H and Wei W*. (2014) Complete Decoding of DNA Recognition by TAL Effector RVDs. Cell Res. 24:628-631.