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联系方式

E-mail:hesheng@biopic.pku.edu.cn
办公电话:(010)80726688-8751
办公地点:昌平区中关村生命科学园28号

研究组主页:

刘河生
BIOPIC客座教授
个人履历

2021-现在   北京大学,北京大学生物医学前沿创新中心(BIOPIC),教授

2021-现在   昌平实验室,脑科学与类脑研究部,首席科学家

2019-2021   美国南卡罗莱纳医科大学,神经科学系,Smart State讲席教授

2019-2021   美国南卡罗莱纳医科大学,神经影像计算中心,主任

2012-2019   美国哈佛大学附属麻省总医院,脑个体差异实验室,主任

2016-2019   美国哈佛大学医学院,放射学系,副教授

2012-2016   美国哈佛大学医学院,放射学系,助理教授

2009-2012   美国哈佛大学医学院,放射学系,讲师

2006-2009   美国哈佛大学附属麻省总医院,放射学系,博士后

2004-2006   美国华盛顿州立大学,计算机科学,博士后

2003,清华大学,工学博士

1997,清华大学,工学学士

主要研究方向

刘河生教授实验室长期从事脑功能成像研究,致力于将脑功能成像技术推向重大脑疾病的临床应用。研究方向包括(1)个体上的大脑功能区的精准剖分。发展可靠、精准的个体化脑功能区剖分技术,研究大脑的社会认知、情感、记忆、语言等基础认知功能;(2)重大脑疾病的临床转化研究。基于个体化脑成像分析技术识别神经精神以及儿童发育,如情绪障碍、孤独症、卒中、帕金森等脑疾病的生物学标记物,优化患者的治疗和康复;(3)重大脑疾病的临床干预的设备研发。

获奖及荣誉

2021年 科技部创新人才

2021年 美国国际创伤后应激障碍学会Pierre Janet最佳论文奖

2019年 美国南卡罗来纳州 Smart State Endowed Chair

2013年 脑与行为研究基金会(NARSAD)青年研究员奖

代表性论文及论著

刘河生教授为第一作者或通讯作者

Google 学术:https://scholar.google.com/citations?hl=zh-CN&user=86URon8AAAAJ

1.Peng X, Liu Q, Hubbard C, Wang D, Zhu W, Fox MD, Liu H., Robust dynamic brain coactivation states estimated in individuals, Science Advances, 2022

2.Trambaiolli, L. R., Peng, X., Lehman, J. F., Linn, G., Russ, B. E., Schroeder, C. E., Liu, H. #, Haber, S. N. #, “Anatomical and functional connectivity support the existence of a salience network node within the caudal ventrolateral prefrontal cortex”, Elife, 11, 2022.

3.Cui W, Wang Y, Ren J, Hubbard CS, Fu X, Fang S, Wang D, Zhang H, Li Y, Li L, Jiang T., Liu H. “Personalized fMRI delineates functional regions preserved within brain tumors”. Annals of neurology, 2021.

4.Wang D., Peng X., Pelletier-Baldelli A., Orlov N., Farabaugh A., Nasr S., Eryilmaz H., Fava M., Holmes A., Roffman J.L., Liu H. #, Holt D. #, “Altered temporal, but intact spatial, features of transient network dynamics in psychosis”, Molecular Psychiatry, 2021

5.Yan Y., Dahmani L., Ren J., Shen L., Peng X., Wang R., He C., Jiang C., Gong C., Tian Y., Zhang J., Guo Y., Lin Y., Li S., Wang M., Li L., Hong B., Liu H., "Reconstructing lost BOLD signal in individual participants using deep machine learning", Nature Communications, 2020

6.Stoecklein S., Hilgendorff A., Li M., Förster K., Flemmer A.W., Galiè F., Wunderlich S., Wang D., Stein S., Ehrhardt H., Dietrich O., Zou Q., Zhou S., Ertl-Wagner B., Liu H. “Variable Functional Connectivity Architecture of the Preterm Human Brain: Impact of Developmental Cortical Expansion and Maturation” Proc Natl Acad Sci USA, 2020

7.Lebois L., Li M., Baker J.T., Wolff J., Wang D., Grinspoon E., Winternitz S., Ren J., Ressler K., Liu H. #, Kaufman M. #, “Large-scale functional brain network architecture changes associated with trauma-related dissociation”, Am. J. Psychiatry, 2020

8.Shen L., Jiang C., Hubbard C.S., Ren J., He C., Wang D., Dahmani L., Guo Y., Liu Y., Xu S., Meng F., Zhang J., Liu H.# , Li L. # “Subthalamic nucleus deep brain stimulation modulates two distinct neurocircuits”, Annals of Neurology, 2020

9.Stoecklein, V.M., Stoecklein, S., Galiè, F., Ren, J., Schmutzer, M., Unterrainer, M., Albert, N.L., Kreth, F.W., Thon, N., Liebig, T. and Ertl-Wagner, B., Tonn J.C., Liu H. “Resting-state fMRI Detects Alterations in Whole Brain Connectivity Related to Tumor Biology in Glioma Patients.” Neuro-Oncology. 2020

10.Liu H., Xiaolong Peng X., Dahmani L., Wang H. , Zhang  M., Shan  Y., Rong D., Guo Y., Li J., Li  N., Wang L., Lin Y., Pan R. Lu J., Wang D., “Different stroke-induced striatal lesions lead to differential structural brain reorganization” Neurology, 2020

11.Wang D., Li M., Wang M., Schoppe F., Ren J., Chen H., Ongur D., Baker J.T., Liu H., “Individual-specific functional connectivity markers track dimensional and categorical features of psychotic illness”, Molecular Psychiatry, 2020

12.Li M., Wang D., Ren J., Langs G., Stoecklein S., Brennan B.P., Lu J., Chen H., Liu H., “Performing group-level functional image analyses based on homologous functional regions mapped in individuals”, PLoS Biology, 2019

13.Tang W.#, Liu H.#, Douw L., Kramer M.A., Eden U.T., Hämäläinen M.S., Stufflebeam S.M., Dynamic connectivity modulates local activity in the core regions of the default-mode”, Proc Natl Acad Sci USA,2017

14.Wang D, Buckner RL, Fox MD, Holt DJ, Holmes AJ, Mueller S, Langs G, Pan R, Qian T, Li K, Baker J, Stufflebeam SM, Wang K, Wang X, Hong B, Liu H. “Parcellating Cortical Functional Networks in Individuals”. Nature Neuroscience, 2015

15.Mueller S., Wang D., Pan R., Holt D., Liu H., “Abnormalities in hemispheric specialization of caudate nucleus connectivity in schizophrenia”, JAMA Psychiatry, 2015

16.Zeng L., Wang D., Fox M.D., Sabuncu M., Hu D., Ge M., Buckner R.L., Liu H., “Neurobiological basis of head motion in brain imaging”. Proc Natl Acad Sci USA, 2014

17.Mueller S., Wang D., Fox M.D., Yeo B.T.T., Sepulcre J., Sabuncu M.R., Shafee R., Lu J., Liu H., “Individual variability in functional connectivity architecture of the human brain”, Neuron, 2013

18.Liu H., Stufflebeam S.M., Sepulcre J., Hedden T., Buckner R.L., “Evidence from Intrinsic Activity that Asymmetry of the Human Brain is Controlled by Multiple Factors”, Proc Natl Acad Sci USA, 2009.

19.Liu. H., Agam Y., Madsen J.R., Kreiman G., “Timing, timing, timing: fast decoding of object information from intracranial field potentials in human visual cortex”, Neuron, 2009.