首页» 中心PI» 曹云龙
联系方式

E-mail:yunlongcao@pku.edu.cn
办公地点:综合科研2号楼102室

研究组主页:http://yunlongcaolab.com/

曹云龙
BIOPIC研究员
个人履历

2024-至今 北大-清华生命科学联合中心,研究员、博士生导师
2023-至今 北京大学生物医学前沿创新中心(BIOPIC),研究员、tenure-track助理教授
2020-至今 昌平国家实验室,研究员、领衔科学家

2022-2023 北京大学生物医学前沿创新中心(BIOPIC),副研究员
2019-2022 北京大学生物医学前沿创新中心(BIOPIC),助理研究员
2014-2019 哈佛大学,化学与化学生物学系,化学(博士) 
2010-2014 浙江大学,竺可桢学院,物理(学士)

主要研究方向

曹云龙课题组致力于在单细胞和分子水平开展体液免疫与抗体研究,聚焦以下研究方向:

  • 传染性疾病中的抗体响应、免疫逃逸与免疫印迹;
  • 广谱抗体药物开发与广谱疫苗设计;
  • 解析不同表位抗体的功能差异及其机制;
  • 基于高通量实验数据与机器学习模型的抗原表位特异性抗体人工设计。
获奖及荣誉
2023  2022年度北京市杰出青年中关村奖
2023  WHO新冠疫苗成分技术指导委员会(TAG-CO-VAC)顾问
2023  流行病防范创新联盟(CEPI)科学咨询委员会委员
2023   2022年度中国科学十大进展
2023   2022年度中国生命科学十大进展
2022   2022年度 Nature 十大人物
2022   国家自然科学基金委优秀青年科学基金
2022  《麻省理工科技评论》2021 年度中国“35 岁以下科技创新 35 人”(TR35)
 
代表性论文及论著
  1. A. Yisimayi#, W. Song#, J. Wang#, F. Jian#, Y. Yu#, X. Chen#, Y. Xu#, S. Yang, X. Niu, T. Xiao, J. Wang, L. Zhao, H. Sun, R. An, N. Zhang, Y. Wang, P. Wang, L. Yu, Z. Lv, Q. Gu, F. Shao, R. Jin, Z. Shen, X. S. Xie, Y. Wang & Y. Cao*, Repeated Omicron exposures override ancestral SARS-CoV-2 immune imprinting. Nature. 625: 148-156. (2024).

  2. Y. Cao*#, F. Jian#, J. Wang#, Y. Yu#, W. Song#, A. Yisimayi, J. Wang, R. An, X.Chen, N. Zhang, Y. Wang, P. Wang,L. Zhao, H. Sun, L. Yu, S. Yang, X. Niu, T. Xiao, Q. Gu, F. Shao, X. Xiao, Y. Xu, R. Jin, Z. Shen, Y. Wang* & X.S. Xie*, Imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution. Nature. 614: 21-529. (2023).

  3. Y. Cao*#, A. Yisimayi#, F. Jian#, W. Song#, T. Xiao#, L. Wang#, S. Du#, J. Wang#, Q. Li#, X. Chen#, Y. Yu#, P. Wang,Z. Zhang, P. Liu, R. An, X. Hao, Y. Wang, J. Wang, R. Feng, H. Sun, L. Zhao, W. Zhang, D. Zhao, J. Zheng, L. Y,C. Li, N. Zhang, R. Wang, X. Niu, S. Yang, X. Song, Y. Chai, Y. Hu, Y. Shi, L. Zheng, Z. Li, Q. Gu, F. Shao, W.Huang, R. Jin, Z. Shen*, Y. Wang*, X. Wang*, J. Xiao* & X. S. Xie*, BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection. Nature. 608: 593-602. (2022).

  4. Y. Cao*#, J. Wang#, F. Jian#, T. Xiao#, W. Song#, A. Yisimayi#, W. Huang#, Q. Li, P. Wang, R. An, J. Wang, Y. Wang, X. Niu, S. Yang, H. Liang, H. Sun, T. Li, Y. Yu, Q. Cui, S. Liu, X. Yang, S. Du, Z. Zhang, X. Hao, F. Shao,R. Jin, X. Wang*, J. Xiao*, Y. Wang* & X. S. Xie*, Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies. Nature. 602: 657-663. (2022).

  5. Y. Cao#, B. Su#, X. Guo#, W. Sun#, Y. Deng#, L. Bao#, Q. Zhu, X. Zhang, Y. Zheng, C. Geng, X. Chai, R. He, X. Li,Q. Lv, H. Zhu, W. Deng, Y. Xu, Y. Wang, L. Qiao, Y. Tan, L. Song, G. Wang, X. Du, N. Gao, J. Liu, J. Xiao, X. Su,Z. Du, Y. Feng, C. Qin*, C. Qin*, R. Jin*, X. S. Xie*, Potent Neutralizing Antibodies against SARS-CoV-2 Identified by High-Throughput Single-Cell Sequencing of Convalescent Patients’ B Cells. Cell. 182: 73-84.e16 (2020).

  6. S. Yang#, Y. Yu#, Y. Xu, F. Jian, W. Song, A. Yisimayi, P. Wang, J. Wang, J. Liu, L. Yu, X. Niu, J. Wang, Y. Wang, F. Shao, R. Jin, Y. Wang, Y. Cao*, Fast evolution of SARS-CoV-2 BA.2.86 to JN.1 under heavy immune pressure. The Lancet Infectious Diseases. 24(2): e70-e72 (2024).

  7. S. Yang#, Y. Yu#, F. Jian, W. Song, A. Yisimayi, X. Chen, Y. Xu, P. Wang, J. Wang, L. Yu, X. Niu, J. Wang, T. Xiao, R. An, Y. Wang, Q. Gu, F. Shao, R. Jin, Z. Shen, Y. Wang, Y. Cao*, Antigenicity and infectivity characterization of SARS-CoV-2 BA.2.86. The Lancet Infectious Diseases. 23(11): e457-e459 (2023).

  8. C. Yue, W. Song, L. Wang, F. Jian, X. Chen, F. Gao, Z. Shen, Y. Wang, X. Wang*, Y. Cao*, ACE2 binding and antibody evasion in enhanced transmissibility of XBB.1.5. The Lancet Infectious Diseases. 23(3):278-280 (2023).

  9. Z. Cui#, P. Liu#, N. Wang#, L. Wang#, K. Fan#, Q. Zhu#, K. Wang#, R. Chen, R. Feng, Z. Jia, M. Yang, G. Xu, B. Zhu, W. Fu, T. Chu, L. Feng, Y. Wang, X. Pei, P. Yang, X. S. Xie, L. Cao*, Y. Cao*, X. Wang*, Structural and functional characterizations of infectivity and immune evasion of SARS-CoV-2 Omicron. Cell. 185(5): 860-871. (2022).

  10. S. Du#, Y. Cao#, Q. Zhu#, P. Yu#, F. Qi#, G. Wang, ...A. Yisimayi, Q. Lv, B. Wang, R. He, Y. Han, W. Zhao, Y. Bai, Y. Qu, X. Gao, C. Ji,Q. Wang, N. Gao, W. Huang, Y. Wang, X. S. Xie*, X. Su*, J. Xiao*, C. Qin*, Structurally Resolved SARS-CoV-2 Antibody Shows High Efficacy in Severely Infected Hamsters and Provides a Potent Cocktail Pairing Strategy. Cell. 183: 1013-1023.e13 (2020).