2025-07 至 今，北京大学生物医学前沿创新中心(BIOPIC)，教授

2020-10 至 2022-04，北京大学，北京未来基因诊断高精尖创新中心, 研究员

2014-01 至 今，北京大学生命科学学院，助理教授、长聘副教授、博雅特聘教授

2014-01 至 今，北大清华生命科学联合中心，研究员

2009-03 至 2013-12，加州大学圣地亚哥分校，博士后、项目科学家

2003-08 至 2008-12，密歇根大学，生物化学系，理学博士

2002-08 至 2003-07，北京大学，生命科学学院，研究助理

1998-09 至 2002-07，北京大学，生物化学及分子生物学系，理学学士

课题组关注免疫相关分子的功能机制，聚焦不同免疫球蛋白与其特异性受体、病原体分子之间的相互作用，以及补体蛋白与免疫球蛋白的互作和调控。基于对这些分子体系的深入理解，也将探索新型抗体设计策略，为相关疾病的治疗提供创新方案。

2023，谈家桢生命科学创新奖

2023，国家自然科学基金委杰出青年基金

2021，药明康德生命化学研究杰出成就奖

2021，顾孝诚讲座奖

2020，中源协和生命医学创新突破奖

​(*indicates corresponding or co-corresponding authors)

1. Deng, M., Du, S.*, Hou, H., Xiao, J.* (2024). Structural insights into the high-affinity IgE receptor FcεRI complex. Nature 633:952-959.

2. Wang, Y., Su, C., Ji, C., Xiao, J.* (2024). CD5L associates with IgM via the J chain. Nature Communications 15:8397.

3. Yang X, Zhu M, Lu X, Wang Y, Xiao J. * (2024). Architecture and activation of human muscle phosphorylase kinase. Nature Communications 15:2719.

4. Li, Y., Shen, H., Zhang, R., Ji, C., Wang, Y., Su, C., Xiao, J.* (2023). Immunoglobulin M Perception by FcμR. Nature 615:907-912.

5. Ji, C., Shen, H., Su, C., Li, Y., Chen, S., Sharp, T.H., Xiao, J.* (2023). Plasmodium falciparum has evolved multiple mechanisms to hijack human immunoglobulin M. Nature Communications 14:2650.

6. Cao, Y.*, Yisimayi, A., Jian, F., Song, W., Xiao, T., Wang, L., Du, S., Wang, J., Li, Q., Chen, X., Yu, Y., Wang, P., Zhang, Z., Liu, P., An, R., Hao, X., Wang, Y., Wang, J., Feng, R., Sun, H., Zhao, L., Zhang, W., Zhao, D., Zheng, J., Yu, L., Li, C., Zhang, N., Wang, R., Niu, X., Yang, S., Song, X., Chai, Y., Hu, Y., Shi, Y., Zheng, L., Li, Z., Gu, Q., Shao, F., Huang, W., Jin, R., Shen, Z.*, Wang, Y.*, Wang, X.*, Xiao, J.*, Xie, X.S.* (2022). BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection. Nature 608:593-602.

7. Du, S., Cao, Y., Zhu, Q., Yu, P., Qi. F., Wang, G., Du, X., Bao, L., Deng, W., Zhu, H., Liu, J., Nie, J., Zheng, Y., Liang, H., Liu, R., Gong, S., Xu, H., Yisimayi, A., Lv, Q., Wang, B., He, R., Han, Y., Zhao, W., Bai, Y., Qu, Y., Gao, X., Ji, C., Wang, Q., Gao, N., Huang, W., Wang, Y., Xie, S.X.*, Su, X.-d.*, Xiao, J.*, Qin, C.* (2020). Structurally resolved SARS-CoV-2 antibody shows high efficacy in severely infected hamsters and provides a potent cocktail pairing strategy. Cell 183:1013-1023.e13.

8. Wang, Y., Wang, G., Li, Y., Zhu, Q., Shen, H., Gao, N., Xiao, J.* (2020). Structural insights into secretory immunoglobulin A and its interaction with a pneumococcal adhesin. Cell Research 30:602-609.

9. Li, Y., Wang, G., Li, N., Wang, Y., Zhu, Q., Chu, H., Wu, W., Tan, Y., Yu, F., Su, X.D., Gao, N., Xiao, J.* (2020). Structural insights into immunoglobulin M. Science 367:1014-1017.

10. Zhang, H., Zhu, Q., Cui, J., Wang, Y., Chen, M.J., Guo, X., Tagliabracci, V.S., Dixon, J.E., Xiao, J.* (2018). Structure and evolution of the Fam20 kinases. Nature Communications 9:1218.